Notch signaling: Its essential roles in bone and craniofacial development

Mikhail Pakvasa; Pranav Haravu; Michael Boachie-Mensah; Alonzo Jones; Elam Coalson; Junyi Liao; Zongyue Zeng; Di Wu; Kevin Qin; Xiaoxing Wu; Huaxiu Luo; Jing Zhang; Meng Zhang; Fang He; Yukun Mao; Yongtao Zhang; Changchun Niu; Meng Wu; Xia Zhao; Hao Wang; Linjuan Huang; Deyao Shi; Qing Liu; Na Ni; Kai Fu; Michael J. Lee; Jennifer Moriatis Wolf; Aravind Athiviraham; Sherwin S. Ho; Tong Chuan He; Kelly Hynes; Jason Strelzow; Mostafa El Dafrawy; Russell R. Reid

doi:10.1016/j.gendis.2020.04.006

Notch signaling: Its essential roles in bone and craniofacial development

Mikhail Pakvasa, Pranav Haravu, Michael Boachie-Mensah, Alonzo Jones, Elam Coalson, Junyi Liao, Zongyue Zeng, Di Wu, Kevin Qin, Xiaoxing Wu, Huaxiu Luo, Jing Zhang, Meng Zhang, Fang He, Yukun Mao, Yongtao Zhang, Changchun Niu, Meng Wu, Xia Zhao, Hao WangLinjuan Huang, Deyao Shi, Qing Liu, Na Ni, Kai Fu, Michael J. Lee, Jennifer Moriatis Wolf, Aravind Athiviraham, Sherwin S. Ho, Tong Chuan He, Kelly Hynes, Jason Strelzow, Mostafa El Dafrawy, Russell R. Reid

Research output: Contribution to journal › Review article › peer-review

44 Scopus citations

Abstract

Notch is a cell–cell signaling pathway that is involved in a host of activities including development, oncogenesis, skeletal homeostasis, and much more. More specifically, recent research has demonstrated the importance of Notch signaling in osteogenic differentiation, bone healing, and in the development of the skeleton. The craniofacial skeleton is complex and understanding its development has remained an important focus in biology. In this review we briefly summarize what recent research has revealed about Notch signaling and the current understanding of how the skeleton, skull, and face develop. We then discuss the crucial role that Notch plays in both craniofacial development and the skeletal system, and what importance it may play in the future.

Original language	English
Pages (from-to)	8-24
Number of pages	17
Journal	Genes and Diseases
Volume	8
Issue number	1
DOIs	https://doi.org/10.1016/j.gendis.2020.04.006
State	Published - Jan 2021

Keywords

Alagille syndrome
Bone
Craniofacial development
Craniosynostosis
Notch
Oncogenesis
Osteogenesis
Spondylocostal dysosotosis

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10.1016/j.gendis.2020.04.006

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Pakvasa, M., Haravu, P., Boachie-Mensah, M., Jones, A., Coalson, E., Liao, J., Zeng, Z., Wu, D., Qin, K., Wu, X., Luo, H., Zhang, J., Zhang, M., He, F., Mao, Y., Zhang, Y., Niu, C., Wu, M., Zhao, X., ... Reid, R. R. (2021). Notch signaling: Its essential roles in bone and craniofacial development. Genes and Diseases, 8(1), 8-24. https://doi.org/10.1016/j.gendis.2020.04.006

@article{b29e6241acc9459cb6ac87f0a6bfd5c8,

title = "Notch signaling: Its essential roles in bone and craniofacial development",

abstract = "Notch is a cell–cell signaling pathway that is involved in a host of activities including development, oncogenesis, skeletal homeostasis, and much more. More specifically, recent research has demonstrated the importance of Notch signaling in osteogenic differentiation, bone healing, and in the development of the skeleton. The craniofacial skeleton is complex and understanding its development has remained an important focus in biology. In this review we briefly summarize what recent research has revealed about Notch signaling and the current understanding of how the skeleton, skull, and face develop. We then discuss the crucial role that Notch plays in both craniofacial development and the skeletal system, and what importance it may play in the future.",

keywords = "Alagille syndrome, Bone, Craniofacial development, Craniosynostosis, Notch, Oncogenesis, Osteogenesis, Spondylocostal dysosotosis",

author = "Mikhail Pakvasa and Pranav Haravu and Michael Boachie-Mensah and Alonzo Jones and Elam Coalson and Junyi Liao and Zongyue Zeng and Di Wu and Kevin Qin and Xiaoxing Wu and Huaxiu Luo and Jing Zhang and Meng Zhang and Fang He and Yukun Mao and Yongtao Zhang and Changchun Niu and Meng Wu and Xia Zhao and Hao Wang and Linjuan Huang and Deyao Shi and Qing Liu and Na Ni and Kai Fu and Lee, {Michael J.} and Wolf, {Jennifer Moriatis} and Aravind Athiviraham and Ho, {Sherwin S.} and He, {Tong Chuan} and Kelly Hynes and Jason Strelzow and {El Dafrawy}, Mostafa and Reid, {Russell R.}",

note = "Publisher Copyright: {\textcopyright} 2020 Chongqing Medical University",

year = "2021",

month = jan,

doi = "10.1016/j.gendis.2020.04.006",

language = "English",

volume = "8",

pages = "8--24",

journal = "Genes and Diseases",

issn = "2352-4820",

number = "1",

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Pakvasa, M, Haravu, P, Boachie-Mensah, M, Jones, A, Coalson, E, Liao, J, Zeng, Z, Wu, D, Qin, K, Wu, X, Luo, H, Zhang, J, Zhang, M, He, F, Mao, Y, Zhang, Y, Niu, C, Wu, M, Zhao, X, Wang, H, Huang, L, Shi, D, Liu, Q, Ni, N, Fu, K, Lee, MJ, Wolf, JM, Athiviraham, A, Ho, SS, He, TC, Hynes, K , Strelzow, J, El Dafrawy, M & Reid, RR 2021, 'Notch signaling: Its essential roles in bone and craniofacial development', Genes and Diseases, vol. 8, no. 1, pp. 8-24. https://doi.org/10.1016/j.gendis.2020.04.006

TY - JOUR

T1 - Notch signaling

T2 - Its essential roles in bone and craniofacial development

AU - Pakvasa, Mikhail

AU - Haravu, Pranav

AU - Boachie-Mensah, Michael

AU - Jones, Alonzo

AU - Coalson, Elam

AU - Liao, Junyi

AU - Zeng, Zongyue

AU - Wu, Di

AU - Qin, Kevin

AU - Wu, Xiaoxing

AU - Luo, Huaxiu

AU - Zhang, Jing

AU - Zhang, Meng

AU - He, Fang

AU - Mao, Yukun

AU - Zhang, Yongtao

AU - Niu, Changchun

AU - Wu, Meng

AU - Zhao, Xia

AU - Wang, Hao

AU - Huang, Linjuan

AU - Shi, Deyao

AU - Liu, Qing

AU - Ni, Na

AU - Fu, Kai

AU - Lee, Michael J.

AU - Wolf, Jennifer Moriatis

AU - Athiviraham, Aravind

AU - Ho, Sherwin S.

AU - He, Tong Chuan

AU - Hynes, Kelly

AU - Strelzow, Jason

AU - El Dafrawy, Mostafa

AU - Reid, Russell R.

PY - 2021/1

Y1 - 2021/1

N2 - Notch is a cell–cell signaling pathway that is involved in a host of activities including development, oncogenesis, skeletal homeostasis, and much more. More specifically, recent research has demonstrated the importance of Notch signaling in osteogenic differentiation, bone healing, and in the development of the skeleton. The craniofacial skeleton is complex and understanding its development has remained an important focus in biology. In this review we briefly summarize what recent research has revealed about Notch signaling and the current understanding of how the skeleton, skull, and face develop. We then discuss the crucial role that Notch plays in both craniofacial development and the skeletal system, and what importance it may play in the future.

AB - Notch is a cell–cell signaling pathway that is involved in a host of activities including development, oncogenesis, skeletal homeostasis, and much more. More specifically, recent research has demonstrated the importance of Notch signaling in osteogenic differentiation, bone healing, and in the development of the skeleton. The craniofacial skeleton is complex and understanding its development has remained an important focus in biology. In this review we briefly summarize what recent research has revealed about Notch signaling and the current understanding of how the skeleton, skull, and face develop. We then discuss the crucial role that Notch plays in both craniofacial development and the skeletal system, and what importance it may play in the future.

KW - Alagille syndrome

KW - Bone

KW - Craniofacial development

KW - Craniosynostosis

KW - Notch

KW - Oncogenesis

KW - Osteogenesis

KW - Spondylocostal dysosotosis

UR - http://www.scopus.com/inward/record.url?scp=85083640211&partnerID=8YFLogxK

U2 - 10.1016/j.gendis.2020.04.006

DO - 10.1016/j.gendis.2020.04.006

M3 - Review article

AN - SCOPUS:85083640211

SN - 2352-4820

VL - 8

SP - 8

EP - 24

JO - Genes and Diseases

JF - Genes and Diseases

IS - 1

ER -

Notch signaling: Its essential roles in bone and craniofacial development

Abstract

Keywords

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