TY - JOUR
T1 - Notch Signaling and Immune Regulation in Alloimmunity
AU - Murakami, Naoka
AU - Maillard, Ivan
AU - Riella, Leonardo V.
N1 - Publisher Copyright:
© 2016, Springer International Publishing AG.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Notch signaling plays a pivotal role in the differentiation and fate determination of T cells, B cells, dendritic cells (DCs), and innate lymphoid cells (ILCs). Recent gene-targeting and antibody approaches advanced our knowledge of the importance of Notch signaling in fine-tuning the peripheral immune response. Here, we review current knowledge of the Notch pathway, focusing on solid organ transplant and graft-versus-host disease preclinical models, and discuss the potential of targeting Notch to suppress the immune response and improve transplant outcomes.
AB - Notch signaling plays a pivotal role in the differentiation and fate determination of T cells, B cells, dendritic cells (DCs), and innate lymphoid cells (ILCs). Recent gene-targeting and antibody approaches advanced our knowledge of the importance of Notch signaling in fine-tuning the peripheral immune response. Here, we review current knowledge of the Notch pathway, focusing on solid organ transplant and graft-versus-host disease preclinical models, and discuss the potential of targeting Notch to suppress the immune response and improve transplant outcomes.
KW - Alloimmunity
KW - Graft-versus-host disease
KW - Notch
KW - Transplant
UR - https://www.scopus.com/pages/publications/85090083001
U2 - 10.1007/s40472-016-0126-5
DO - 10.1007/s40472-016-0126-5
M3 - Article
AN - SCOPUS:85090083001
SN - 2196-3029
VL - 3
SP - 294
EP - 302
JO - Current Transplantation Reports
JF - Current Transplantation Reports
IS - 4
ER -