Not so fast: Co-requirements for sonic hedgehog induced brain tumorigenesis

Stacey A. Ward, Joshua B. Rubin

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

The Sonic hedgehog (Shh) pathway plays an integral role in cellular proliferation during normal brain development and also drives growth in a variety of cancers including brain cancer. Clinical trials of Shh pathway inhibitors for brain tumors have yielded disappointing results, indicating a more nuanced role for Shh signaling. We postulate that Shh signaling does not work alone but requires co-activation of other signaling pathways for tumorigenesis and stem cell maintenance. This review will focus on the interplay between the Shh pathway and these pathways to promote tumor growth in brain tumors, presenting opportunities for the study of combinatorial therapies.

Original languageEnglish
Pages (from-to)1484-1498
Number of pages15
JournalCancers
Volume7
Issue number3
DOIs
StatePublished - Aug 6 2015

Keywords

  • Cerebellum
  • GPCR
  • Medulloblastoma
  • Signal transduction
  • Sonic hedgehog

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