Not so fast: Co-requirements for sonic hedgehog induced brain tumorigenesis

Stacey A. Ward; Joshua B. Rubin

doi:10.3390/cancers7030848

Not so fast: Co-requirements for sonic hedgehog induced brain tumorigenesis

Stacey A. Ward, Joshua B. Rubin

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

The Sonic hedgehog (Shh) pathway plays an integral role in cellular proliferation during normal brain development and also drives growth in a variety of cancers including brain cancer. Clinical trials of Shh pathway inhibitors for brain tumors have yielded disappointing results, indicating a more nuanced role for Shh signaling. We postulate that Shh signaling does not work alone but requires co-activation of other signaling pathways for tumorigenesis and stem cell maintenance. This review will focus on the interplay between the Shh pathway and these pathways to promote tumor growth in brain tumors, presenting opportunities for the study of combinatorial therapies.

Original language	English
Pages (from-to)	1484-1498
Number of pages	15
Journal	Cancers
Volume	7
Issue number	3
DOIs	https://doi.org/10.3390/cancers7030848
State	Published - Aug 6 2015

Keywords

Cerebellum
GPCR
Medulloblastoma
Signal transduction
Sonic hedgehog

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10.3390/cancers7030848

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title = "Not so fast: Co-requirements for sonic hedgehog induced brain tumorigenesis",

abstract = "The Sonic hedgehog (Shh) pathway plays an integral role in cellular proliferation during normal brain development and also drives growth in a variety of cancers including brain cancer. Clinical trials of Shh pathway inhibitors for brain tumors have yielded disappointing results, indicating a more nuanced role for Shh signaling. We postulate that Shh signaling does not work alone but requires co-activation of other signaling pathways for tumorigenesis and stem cell maintenance. This review will focus on the interplay between the Shh pathway and these pathways to promote tumor growth in brain tumors, presenting opportunities for the study of combinatorial therapies.",

keywords = "Cerebellum, GPCR, Medulloblastoma, Signal transduction, Sonic hedgehog",

author = "Ward, {Stacey A.} and Rubin, {Joshua B.}",

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AU - Ward, Stacey A.

AU - Rubin, Joshua B.

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N2 - The Sonic hedgehog (Shh) pathway plays an integral role in cellular proliferation during normal brain development and also drives growth in a variety of cancers including brain cancer. Clinical trials of Shh pathway inhibitors for brain tumors have yielded disappointing results, indicating a more nuanced role for Shh signaling. We postulate that Shh signaling does not work alone but requires co-activation of other signaling pathways for tumorigenesis and stem cell maintenance. This review will focus on the interplay between the Shh pathway and these pathways to promote tumor growth in brain tumors, presenting opportunities for the study of combinatorial therapies.

AB - The Sonic hedgehog (Shh) pathway plays an integral role in cellular proliferation during normal brain development and also drives growth in a variety of cancers including brain cancer. Clinical trials of Shh pathway inhibitors for brain tumors have yielded disappointing results, indicating a more nuanced role for Shh signaling. We postulate that Shh signaling does not work alone but requires co-activation of other signaling pathways for tumorigenesis and stem cell maintenance. This review will focus on the interplay between the Shh pathway and these pathways to promote tumor growth in brain tumors, presenting opportunities for the study of combinatorial therapies.

KW - Cerebellum

KW - GPCR

KW - Medulloblastoma

KW - Signal transduction

KW - Sonic hedgehog

UR - http://www.scopus.com/inward/record.url?scp=84940990696&partnerID=8YFLogxK

U2 - 10.3390/cancers7030848

DO - 10.3390/cancers7030848

M3 - Review article

AN - SCOPUS:84940990696

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VL - 7

SP - 1484

EP - 1498

JO - Cancers

JF - Cancers

IS - 3

ER -

Not so fast: Co-requirements for sonic hedgehog induced brain tumorigenesis

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Keywords

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