Not just for muscle anymore: Activity and calcium regulation of MEF2-dependent transcription in neuronal survival and differentiation

Aryaman Shalizi, Azad Bonni

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations

Abstract

Post-mitotic neurons of the central nervous system express one or more MEF2 proteins from the time of cell-cycle exit through adulthood. Furthermore, it is now evident that MEF2 regulates diverse aspects of neuronal development including cell survival and synaptogenesis. MEF2 proteins are bifunctional transcriptional regulators, a property that arises from the signal-dependent association of MEF2 proteins with distinct chromatin modifying activities. The goal of this chapter is to provide an account of the various control mechanisms that MEF2 proteins are subjected to within the central nervous system, placing a specific emphasis on the contribution of activity- and calcium-dependent signaling pathways.

Original languageEnglish
Title of host publicationTranscriptional Regulation by Neuronal Activity
Subtitle of host publicationTo the Nucleus and Back
PublisherSpringer US
Pages229-250
Number of pages22
ISBN (Electronic)9780387736099
ISBN (Print)9780387736082
DOIs
StatePublished - Jan 1 2008

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