TY - JOUR
T1 - Nosocomial outbreak of vancomycin-resistant Enterococcus faecium (VRE) ST796, Switzerland, 2017 to 2020
AU - Piezzi, Vanja
AU - Wassilew, Nasstasja
AU - Atkinson, Andrew
AU - D'Incau, Stephanie
AU - Kaspar, Tanja
AU - Seth-Smith, Helena M.B.
AU - Casanova, Carlo
AU - Bittel, Pascal
AU - Jent, Philipp
AU - Sommerstein, Rami
AU - Buetti, Niccolo
AU - Marschall, Jonas
N1 - Publisher Copyright:
© 2022 European Centre for Disease Prevention and Control (ECDC). All rights reserved.
PY - 2022/12/1
Y1 - 2022/12/1
N2 - A large clonal outbreak caused by vancomycin-resistant Enterococcus faecium (VRE) affected the Bern University Hospital group from the end of December 2017 until July 2020. We describe the characteristics of the outbreak and the bundle of infection prevention and control (IPC) measures implemented. The outbreak was first recognised when two concomitant cases of VRE bloodstream infection were identified on the oncology ward. During 32 months, 518 patients in the 1,300-bed hospital group were identified as vanB VRE carriers. Eighteen (3.5%) patients developed an invasive infection, of whom seven had bacteraemia. In 2018, a subset of 328 isolates were analysed by whole genome sequencing, 312 of which were identified as sequence type (ST) 796. The initial IPC measures were implemented with a focus on the affected wards. However, in June 2018, ST796 caused another increase in cases, and the management strategy was intensified and escalated to a hospital-wide level. The clinical impact of this large nosocomial VRE outbreak with the emergent clone ST796 was modest. A hospital-wide approach with a multimodal IPC bundle was successful against this highly transmissible strain.
AB - A large clonal outbreak caused by vancomycin-resistant Enterococcus faecium (VRE) affected the Bern University Hospital group from the end of December 2017 until July 2020. We describe the characteristics of the outbreak and the bundle of infection prevention and control (IPC) measures implemented. The outbreak was first recognised when two concomitant cases of VRE bloodstream infection were identified on the oncology ward. During 32 months, 518 patients in the 1,300-bed hospital group were identified as vanB VRE carriers. Eighteen (3.5%) patients developed an invasive infection, of whom seven had bacteraemia. In 2018, a subset of 328 isolates were analysed by whole genome sequencing, 312 of which were identified as sequence type (ST) 796. The initial IPC measures were implemented with a focus on the affected wards. However, in June 2018, ST796 caused another increase in cases, and the management strategy was intensified and escalated to a hospital-wide level. The clinical impact of this large nosocomial VRE outbreak with the emergent clone ST796 was modest. A hospital-wide approach with a multimodal IPC bundle was successful against this highly transmissible strain.
UR - http://www.scopus.com/inward/record.url?scp=85144416253&partnerID=8YFLogxK
U2 - 10.2807/1560-7917.ES.2022.27.48.2200285
DO - 10.2807/1560-7917.ES.2022.27.48.2200285
M3 - Article
C2 - 36695463
AN - SCOPUS:85144416253
SN - 1025-496X
VL - 27
JO - Eurosurveillance
JF - Eurosurveillance
IS - 48
ER -