Nortriptyline pharmacokinetics and plasma levels: Implications for clinical practice

E. H. Rubin, J. T. Biggs, S. H. Preskorn

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

The pharmacokinetics of TCAs are reviewed with particular emphasis on nortriptyline, the agent most extensively studied. The clinical uses of TCA plasma level-response studies are discussed in relationship to rational dosage adjustment to increase response rates and avoid iatrogenic toxicity. Other important topics discussed include the issue of active metabolites, single-dose prediction studies, and special considerations in treating the elderly and the medically ill.

Original languageEnglish
Pages (from-to)418-424
Number of pages7
JournalJournal of Clinical Psychiatry
Volume46
Issue number10
StatePublished - Dec 1 1985

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