TY - JOUR
T1 - Norovirus Regulation by Host and Microbe
AU - Baldridge, Megan T.
AU - Turula, Holly
AU - Wobus, Christiane E.
N1 - Funding Information:
M.T.B. was supported by National Institutes of Health (NIH) training grant T32CA009547. Work in the laboratory of C.E.W. was supported by NIH grants AI102106, AI080611, and AI103961. H.T. was supported in part by a University of Michigan Rackham Merit fellowship and NIH training grants T32AI007413 and T32DK094775.
Publisher Copyright:
© 2016 Elsevier Ltd
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Norovirus (NoV) infection is the leading cause of epidemic gastroenteritis globally, and can lead to detrimental chronic infection in immunocompromised hosts. Despite its prevalence as a cause of diarrheal illness, the study of human NoVs (HNoVs) has historically been limited by a paucity of models. The use of murine NoV (MNoV) to interrogate mechanisms of host control of viral infection has facilitated the exploration of different genetic mouse models, revealing roles for both innate and adaptive immunity in viral regulation. MNoV studies have also recently identified important interactions between the commensal microbiota and NoV with clear extensions to HNoVs. In this review, we discuss the most current understanding of how the host, the microbiome, and their interactions regulate NoV infections.
AB - Norovirus (NoV) infection is the leading cause of epidemic gastroenteritis globally, and can lead to detrimental chronic infection in immunocompromised hosts. Despite its prevalence as a cause of diarrheal illness, the study of human NoVs (HNoVs) has historically been limited by a paucity of models. The use of murine NoV (MNoV) to interrogate mechanisms of host control of viral infection has facilitated the exploration of different genetic mouse models, revealing roles for both innate and adaptive immunity in viral regulation. MNoV studies have also recently identified important interactions between the commensal microbiota and NoV with clear extensions to HNoVs. In this review, we discuss the most current understanding of how the host, the microbiome, and their interactions regulate NoV infections.
KW - immunity
KW - microbiome
KW - microbiota
KW - norovirus
UR - http://www.scopus.com/inward/record.url?scp=84999693682&partnerID=8YFLogxK
U2 - 10.1016/j.molmed.2016.10.003
DO - 10.1016/j.molmed.2016.10.003
M3 - Review article
C2 - 27887808
AN - SCOPUS:84999693682
SN - 1471-4914
VL - 22
SP - 1047
EP - 1059
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 12
ER -