Normal range of bleeding scores for the ISTH-BAT: Adult and pediatric data from the merging project

Zimmerman Program Investigators

Research output: Contribution to journalArticlepeer-review

157 Scopus citations

Abstract

Bleeding Assessment Tools (BATs) have been developed to aid in the standardized evaluation of bleeding symptoms. The Vicenza Bleeding Questionnaire (BQ), published in 2005, established a common framework and scoring key that has undergone subsequent modification over the years, culminating in the publication of the ISTH-BAT in 2010. Understanding the normal range of bleeding scores is critical when assessing the utility of a BAT. Within the context of The Merging Project, a bioinformatics system was created to facilitate the merging of legacy data derived from four different (but all Vicenza-based) BATs; the MCMDM1-VWD BQ, the Condensed MCMDM-1VWD BQ, the Pediatric Bleeding Questionnaire and the ISTH-BAT. Data from 1040 normal adults and 328 children were included in the final analysis, which showed that the normal range is 0-3 for adult males, 0-5 for adult females and 0-2 in children for both males and females. Therefore, the cut-off for a positive or abnormal BS is ≥4 in adult males, ≥6 in adult females and ≥3 in children. This information can now be used to objectively assess bleeding symptoms as normal or abnormal in future studies.

Original languageEnglish
Pages (from-to)831-835
Number of pages5
JournalHaemophilia
Volume20
Issue number6
DOIs
StatePublished - Nov 1 2014

Keywords

  • Bleeding questionnaire
  • Bleeding score
  • ISTH-BAT
  • Normal range

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