Normal platelet mitochondrial complex I activity in Huntington's Disease

William J. Powers, Richard H. Haas, Thuy Le, Tom O. Videen, Tamara Hershey, Lori McGee-Minnich, Joel S. Perlmutter

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Two small case series of platelet mitochondrial complex I activity assays in Huntington's Disease (HD) report discrepant results. We measured platelet complex I and complex I/III activity in 21 subjects with early gene-positive HD and 14 age-matched controls. The 21 participants with HD that we studied are greater than the total of 16 in the two previously published of platelet ETS activity in HD. Reductions ?>> 10% were excluded with 80% confidence. A systemic defect in complex I activity is not present in early HD when striatal neuronal degeneration is already present.

Original languageEnglish
Pages (from-to)99-101
Number of pages3
JournalNeurobiology of Disease
Volume27
Issue number1
DOIs
StatePublished - Jul 1 2007

Keywords

  • Electron transport system
  • Human
  • Huntington's Disease
  • Mitochondria
  • Platelets

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