@article{ccd8b18663e346bab1913b34e3b8cd6c,
title = "Normal platelet mitochondrial complex I activity in Huntington's Disease",
abstract = "Two small case series of platelet mitochondrial complex I activity assays in Huntington's Disease (HD) report discrepant results. We measured platelet complex I and complex I/III activity in 21 subjects with early gene-positive HD and 14 age-matched controls. The 21 participants with HD that we studied are greater than the total of 16 in the two previously published of platelet ETS activity in HD. Reductions ?>> 10% were excluded with 80% confidence. A systemic defect in complex I activity is not present in early HD when striatal neuronal degeneration is already present.",
keywords = "Electron transport system, Human, Huntington's Disease, Mitochondria, Platelets",
author = "Powers, {William J.} and Haas, {Richard H.} and Thuy Le and Videen, {Tom O.} and Tamara Hershey and Lori McGee-Minnich and Perlmutter, {Joel S.}",
note = "Funding Information: This research was supported by USPHS grants NS41771 and NS35966, the Lillian Strauss Institute for Neuroscience, the Barnes-Jewish Hospital Foundation (the Jack Buck Fund and the Elliot Stein Family Fund), the Huntington{\textquoteright}s Disease Society of America Center of Excellence at Washington University, the American Parkinson Disease Association (APDA) Advanced Center for Research at Washington University and the Greater St. Louis Chapter of the APDA. We thank Clifford Shults (deceased) for his assistance with organizing the study as well as Lennis Lich, John Hood, Susanne Fritsch and the Washington University Cyclotron Staff for their assistance.",
year = "2007",
month = jul,
doi = "10.1016/j.nbd.2007.04.008",
language = "English",
volume = "27",
pages = "99--101",
journal = "Neurobiology of Disease",
issn = "0969-9961",
number = "1",
}