Two small case series of platelet mitochondrial complex I activity assays in Huntington's Disease (HD) report discrepant results. We measured platelet complex I and complex I/III activity in 21 subjects with early gene-positive HD and 14 age-matched controls. The 21 participants with HD that we studied are greater than the total of 16 in the two previously published of platelet ETS activity in HD. Reductions ?>> 10% were excluded with 80% confidence. A systemic defect in complex I activity is not present in early HD when striatal neuronal degeneration is already present.

Original languageEnglish
Pages (from-to)99-101
Number of pages3
JournalNeurobiology of Disease
Issue number1
StatePublished - Jul 2007


  • Electron transport system
  • Human
  • Huntington's Disease
  • Mitochondria
  • Platelets


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