Abstract
The norepinephrine-sensitive adenylate cyclase system in the rat brain was examined. Adrenergic blocking agents and the relative activity of structurally related catecholamines were employed to determine whether norepinephrine-stimulated accumulation of [3H]c-AMP in the hypothalamus occurred via alpha or beta adrenergic receptors. The results indicate that norepinephrine probably acts through a mixture of alpha and beta receptors in that both alpha and beta adrenergic blockers inhibited norepinephrine-induced accumulation of [3H]c-AMP. Morphine and levorphanol had no significant effect on adenylate cyclase or phosphodiesterase activities in hypothalamic slices or homogenates of several brain regions.
| Original language | English |
|---|---|
| Pages (from-to) | 175-188 |
| Number of pages | 14 |
| Journal | Research Communications in Chemical Pathology and Pharmacology |
| Volume | 18 |
| Issue number | 2 |
| State | Published - Dec 1 1977 |