TY - JOUR
T1 - Norepinephrine reverses N-methyl-d-aspartate-mediated inhibition of long-term potentiation in rat hippocampal slices
AU - Izumi, Yukitoshi
AU - Clifford, David B.
AU - Zorumski, Charles F.
N1 - Funding Information:
This work was supported by NIMH Physician Scientist Award MH00630, Grants AG05681 and MH45493, the McDonnell Center For Studies of Higher Brain Function and the Bantly Foundation. The authors thank Drs. John Olney, Jay Yang, Kunio Kato, Liu Lin Thio and James Reggin for many helpful discussions.
PY - 1992/8/17
Y1 - 1992/8/17
N2 - Application of 1 μM N-methyl-d-aspartate (NMDA) either immediately before or following tetanic stimulation inhibits the induction of CA1 hippocampal long-term potentiation (LTP). We have examined the effect of trans-amino-1,3-cyclopentanedicarboxylic acid (ACPD), norepinephrine and acetylcholine on this NMDA-mediated LTP inhibition using extracellular recordings from in vitro rat hippocampal slices. When NMDA is accompanied by 100 μM ACPD or 10 μM norepinephrine, the block of LTP is overcome. The norepinephrine effect is mimicked by phenylephrine and methoxamine and is blocked by phentolamine and prazosin suggesting the involvement of α1-adrenergic receptors.
AB - Application of 1 μM N-methyl-d-aspartate (NMDA) either immediately before or following tetanic stimulation inhibits the induction of CA1 hippocampal long-term potentiation (LTP). We have examined the effect of trans-amino-1,3-cyclopentanedicarboxylic acid (ACPD), norepinephrine and acetylcholine on this NMDA-mediated LTP inhibition using extracellular recordings from in vitro rat hippocampal slices. When NMDA is accompanied by 100 μM ACPD or 10 μM norepinephrine, the block of LTP is overcome. The norepinephrine effect is mimicked by phenylephrine and methoxamine and is blocked by phentolamine and prazosin suggesting the involvement of α1-adrenergic receptors.
KW - Hippocampus
KW - Long-term potentiation
KW - Metabotropic receptor
KW - N-Methyl-d-aspartate
KW - Norepinephrine
UR - http://www.scopus.com/inward/record.url?scp=0026781233&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(92)90364-D
DO - 10.1016/0304-3940(92)90364-D
M3 - Article
C2 - 1360641
AN - SCOPUS:0026781233
SN - 0304-3940
VL - 142
SP - 163
EP - 166
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -