Noradrenergic modulation of hypothalamic progestin receptors in female guinea pigs is specific to the ventromedial nucleus

Janice E. Thornton, Bruce Nock, Bruce S. McEwen, Harvey H. Feder

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Abstract

The concentration of estrogen-induced cytosolic progestin receptors (CPRs) in the hypothalamus of α1-noradrenergic antagonist- treated female guinea pigs is reduced relative to non-drug-treated controls. The present study determined where within the hypothalamus this reduction occurs. Ovariectomized, estradiol-treated guinea pigs were given either the α1-noradrenergic antagonist prazosin or vehicle. Microdissected brain regions were assayed for CPR levels. Prazosin caused a selective relative decrease in CPR levels of the ventromedial nucleus of the hypothalamus. No significant effects of prazosin were seen in other hypothalamic or preoptic area nuclei.

Original languageEnglish
Pages (from-to)155-159
Number of pages5
JournalBrain Research
Volume377
Issue number1
DOIs
StatePublished - Jul 2 1986

Keywords

  • estrogen action
  • guinea pig
  • hypothalamus
  • lordosis behavior
  • noradrenergic transmission
  • prazosin
  • progestin receptor

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