Noradrenergic modulation of hypothalamic progestin receptors in female guinea pigs is specific to the ventromedial nucleus

Janice E. Thornton; Bruce Nock; Bruce S. McEwen; Harvey H. Feder

doi:10.1016/0006-8993(86)91200-X

Noradrenergic modulation of hypothalamic progestin receptors in female guinea pigs is specific to the ventromedial nucleus

Janice E. Thornton, Bruce Nock, Bruce S. McEwen, Harvey H. Feder

Department of Psychiatry

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

The concentration of estrogen-induced cytosolic progestin receptors (CPRs) in the hypothalamus of α1-noradrenergic antagonist- treated female guinea pigs is reduced relative to non-drug-treated controls. The present study determined where within the hypothalamus this reduction occurs. Ovariectomized, estradiol-treated guinea pigs were given either the α1-noradrenergic antagonist prazosin or vehicle. Microdissected brain regions were assayed for CPR levels. Prazosin caused a selective relative decrease in CPR levels of the ventromedial nucleus of the hypothalamus. No significant effects of prazosin were seen in other hypothalamic or preoptic area nuclei.

Original language	English
Pages (from-to)	155-159
Number of pages	5
Journal	Brain Research
Volume	377
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(86)91200-X
State	Published - Jul 2 1986

Keywords

estrogen action
guinea pig
hypothalamus
lordosis behavior
noradrenergic transmission
prazosin
progestin receptor

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10.1016/0006-8993(86)91200-X

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title = "Noradrenergic modulation of hypothalamic progestin receptors in female guinea pigs is specific to the ventromedial nucleus",

abstract = "The concentration of estrogen-induced cytosolic progestin receptors (CPRs) in the hypothalamus of α1-noradrenergic antagonist- treated female guinea pigs is reduced relative to non-drug-treated controls. The present study determined where within the hypothalamus this reduction occurs. Ovariectomized, estradiol-treated guinea pigs were given either the α1-noradrenergic antagonist prazosin or vehicle. Microdissected brain regions were assayed for CPR levels. Prazosin caused a selective relative decrease in CPR levels of the ventromedial nucleus of the hypothalamus. No significant effects of prazosin were seen in other hypothalamic or preoptic area nuclei.",

keywords = "estrogen action, guinea pig, hypothalamus, lordosis behavior, noradrenergic transmission, prazosin, progestin receptor",

author = "Thornton, {Janice E.} and Bruce Nock and McEwen, {Bruce S.} and Feder, {Harvey H.}",

note = "Funding Information: J.E.T. was supportedb y NIMH Training Grant T-32-MH15145-06B. .N. was supportedb y NS 06966. B.S.M. was supportedby NS 07080a ndby institutional Grant RF 81062 from the RockefellerF ounda-tion. H.H.F. was supported by NIH-HD-04467, NIMH-29006 and Busch BequestA ward from Rut-gets University.C ontributionn umber4 37 of the In-stituteo f Animal Behavior and number 006 of the Biology DepartmentR,u tgersU niversity.W e thank CynthiaB anasand Mark Papiannfi or graphics.",

year = "1986",

month = jul,

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doi = "10.1016/0006-8993(86)91200-X",

language = "English",

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T1 - Noradrenergic modulation of hypothalamic progestin receptors in female guinea pigs is specific to the ventromedial nucleus

AU - Thornton, Janice E.

AU - Nock, Bruce

AU - McEwen, Bruce S.

AU - Feder, Harvey H.

N1 - Funding Information: J.E.T. was supportedb y NIMH Training Grant T-32-MH15145-06B. .N. was supportedb y NS 06966. B.S.M. was supportedby NS 07080a ndby institutional Grant RF 81062 from the RockefellerF ounda-tion. H.H.F. was supported by NIH-HD-04467, NIMH-29006 and Busch BequestA ward from Rut-gets University.C ontributionn umber4 37 of the In-stituteo f Animal Behavior and number 006 of the Biology DepartmentR,u tgersU niversity.W e thank CynthiaB anasand Mark Papiannfi or graphics.

PY - 1986/7/2

Y1 - 1986/7/2

N2 - The concentration of estrogen-induced cytosolic progestin receptors (CPRs) in the hypothalamus of α1-noradrenergic antagonist- treated female guinea pigs is reduced relative to non-drug-treated controls. The present study determined where within the hypothalamus this reduction occurs. Ovariectomized, estradiol-treated guinea pigs were given either the α1-noradrenergic antagonist prazosin or vehicle. Microdissected brain regions were assayed for CPR levels. Prazosin caused a selective relative decrease in CPR levels of the ventromedial nucleus of the hypothalamus. No significant effects of prazosin were seen in other hypothalamic or preoptic area nuclei.

AB - The concentration of estrogen-induced cytosolic progestin receptors (CPRs) in the hypothalamus of α1-noradrenergic antagonist- treated female guinea pigs is reduced relative to non-drug-treated controls. The present study determined where within the hypothalamus this reduction occurs. Ovariectomized, estradiol-treated guinea pigs were given either the α1-noradrenergic antagonist prazosin or vehicle. Microdissected brain regions were assayed for CPR levels. Prazosin caused a selective relative decrease in CPR levels of the ventromedial nucleus of the hypothalamus. No significant effects of prazosin were seen in other hypothalamic or preoptic area nuclei.

KW - estrogen action

KW - guinea pig

KW - hypothalamus

KW - lordosis behavior

KW - noradrenergic transmission

KW - prazosin

KW - progestin receptor

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U2 - 10.1016/0006-8993(86)91200-X

DO - 10.1016/0006-8993(86)91200-X

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C2 - 3015344

AN - SCOPUS:0022453201

SN - 0006-8993

VL - 377

SP - 155

EP - 159

JO - Brain Research

JF - Brain Research

IS - 1

ER -

Noradrenergic modulation of hypothalamic progestin receptors in female guinea pigs is specific to the ventromedial nucleus

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