NOP receptor signaling cascades

Kyle E. Parker, Michael R. Bruchas

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

4 Scopus citations

Abstract

The nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor is a G protein-coupled receptor with wide distribution throughout the peripheral and central nervous system. Similar to other opioid receptors, NOP receptors couple to intracellular second messengers and regulatory proteins to affect biological systems. In this chapter, we review the current literature for NOP signaling cascades including their role as classic GPCRs, the investigation of their kinase and arrestin signaling pathways, and the importance of examining biased signaling to critically evaluate the therapeutic potential of novel NOP agonists.

Original languageEnglish
Title of host publicationHandbook of Experimental Pharmacology
PublisherSpringer New York LLC
Pages131-139
Number of pages9
DOIs
StatePublished - 2019

Publication series

NameHandbook of Experimental Pharmacology
Volume254
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

Keywords

  • Arrestin
  • Bias
  • G protein
  • N/OFQ
  • NOP receptors
  • Nociceptin

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