Noninvasive fat quantification of the liver and pancreas may provide potential biomarkers of impaired glucose tolerance and type 2 diabetes

Zhi Dong, Yanji Luo, Huasong Cai, Zhongwei Zhang, Zhenpeng Peng, Mengjie Jiang, Yanbing Li, Chang Li, Zi Ping Li, Shi Ting Feng

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The aim of the study is to investigate if the fat content of the liver and pancreas may indicate impaired glucose tolerance (IGT) or type 2 diabetes mellitus (T2DM). A total of 83 subjects (34 men; aged 46.5±13.5 years) were characterized as T2DM, IGT, or normal glucose tolerant (NGT). NGT individuals were stratified as <40 or ≥40 years. Standard laboratory tests were conducted for insulin resistance and b-cell dysfunction. The magnetic resonance imaging Dixon technique was used to determine fat distribution in the liver and pancreas. Correlations among liver and pancreatic fat volume fractions (LFVFs and PFVFs, respectively) and laboratory parameters were analyzed. Among the groups, fat distribution was consistent throughout sections of the liver and pancreas, and LFVFs closely correlated with PFVFs. LFVFs correlated more closely than PFVFs with insulin resistance and b-cell function. Both the LFVFs and PFVFs were the highest in the T2DM patients, less in the IGT, and least in the NGT; all differences were significant. The PFVFs of the NGT subjects ≥40 years were significantly higher than that of those<40 years. The fat content of the liver and pancreas, particularly the liver, may be a biomarker for IGT and T2DM.

Original languageEnglish
Article numbere3858
JournalMedicine (United States)
Volume95
Issue number23
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Keywords

  • Fat volume fraction
  • Liver
  • Magnetic resonance imaging
  • Pancreas
  • Type 2 diabetes mellitus

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