Noninvasive estimation of the arterial input function in positron emission tomography imaging of cerebral blood flow

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33 Scopus citations

Abstract

Positron emission tomography (PET) with 15 O-labeled water can provide reliable measurement of cerebral blood flow (CBF). Quantification of CBF requires knowledge of the arterial input function (AIF), which is usually provided by arterial blood sampling. However, arterial sampling is invasive. Moreover, the blood generally is sampled at the wrist, which does not perfectly represent the AIF of the brain, because of the effects of delay and dispersion. We developed and validated a new noninvasive method to obtain the AIF directly by PET imaging of the internal carotid artery in a region of interest (ROI) defined by coregistered high-resolution magnetic resonance angiography. An ROI centered at the petrous portion of the internal carotid artery was defined, and the AIF was estimated simultaneously with whole brain blood flow. The image-derived AIF (IDAIF) method was validated against conventional arterial sampling. The IDAIF generated highly reproducible CBF estimations, generally in good agreement with the conventional technique.

Original languageEnglish
Pages (from-to)115-121
Number of pages7
JournalJournal of Cerebral Blood Flow and Metabolism
Volume33
Issue number1
DOIs
StatePublished - Jan 1 2013

Keywords

  • PET
  • arterial input function

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