TY - JOUR
T1 - Noninvasive electromyometrial imaging of human uterine maturation during term labor
AU - Wang, Hui
AU - Wen, Zichao
AU - Wu, Wenjie
AU - Sun, Zhexian
AU - Kisrieva-Ware, Zulfia
AU - Lin, Yiqi
AU - Wang, Sicheng
AU - Gao, Hansong
AU - Xu, Haonan
AU - Zhao, Peinan
AU - Wang, Qing
AU - Macones, George A.
AU - Schwartz, Alan L.
AU - Cuculich, Phillip
AU - Cahill, Alison G.
AU - Wang, Yong
N1 - Funding Information:
We thank Deborah Frank for editing the manuscript; Jessica Chubiz for managing the subject study; Monica Anderson, Tracy Burger, Emily Diveley, Megan Steiner, Stephanie Pizzella, Cassy Hardy, and Bri Dawson for explaining the study to subjects, obtaining consent, and managing the study; and Nina Punyamurthy, Naomi Goldstein, and Josephine Lau Nga Yue for helping with the initial subject experiments; Rebecca Chen and Hanna Aaron for helping with the initial data preprocessing. This work was supported by the March of Dimes Center Grant (22-FY14-486), by grants from NIH/National Institute of Child Health and Human Development (R01HD094381 to PIs Y. Wang/Cahill; R01HD104822 to PIs Y. Wang/Schwartz/Cahill), by grants from Burroughs Wellcome Fund Preterm Birth Initiative (NGP10119 to PI Y. Wang) and by grants from Bill & Melinda Gates Foundation (INV-005417, INV-035476, and INV-037302 to PI Y. Wang).
Publisher Copyright:
© 2023, The Author(s).
PY - 2023/12
Y1 - 2023/12
N2 - Electromyometrial imaging (EMMI) was recently developed to image the three-dimensional (3D) uterine electrical activation during contractions noninvasively and accurately in sheep. Herein we describe the development and application of a human EMMI system to image and evaluate 3D uterine electrical activation patterns at high spatial and temporal resolution during human term labor. We demonstrate the successful integration of the human EMMI system during subjects’ clinical visits to generate noninvasively the uterine surface electrical potential maps, electrograms, and activation sequence through an inverse solution using up to 192 electrodes distributed around the abdomen surface. Quantitative indices, including the uterine activation curve, are developed and defined to characterize uterine surface contraction patterns. We thus show that the human EMMI system can provide detailed 3D images and quantification of uterine contractions as well as novel insights into the role of human uterine maturation during labor progression.
AB - Electromyometrial imaging (EMMI) was recently developed to image the three-dimensional (3D) uterine electrical activation during contractions noninvasively and accurately in sheep. Herein we describe the development and application of a human EMMI system to image and evaluate 3D uterine electrical activation patterns at high spatial and temporal resolution during human term labor. We demonstrate the successful integration of the human EMMI system during subjects’ clinical visits to generate noninvasively the uterine surface electrical potential maps, electrograms, and activation sequence through an inverse solution using up to 192 electrodes distributed around the abdomen surface. Quantitative indices, including the uterine activation curve, are developed and defined to characterize uterine surface contraction patterns. We thus show that the human EMMI system can provide detailed 3D images and quantification of uterine contractions as well as novel insights into the role of human uterine maturation during labor progression.
UR - http://www.scopus.com/inward/record.url?scp=85150312813&partnerID=8YFLogxK
U2 - 10.1038/s41467-023-36440-0
DO - 10.1038/s41467-023-36440-0
M3 - Article
C2 - 36918533
AN - SCOPUS:85150312813
SN - 2041-1723
VL - 14
JO - Nature communications
JF - Nature communications
IS - 1
M1 - 1198
ER -