Noninvasive diffusion tensor imaging of evolving white matter pathology in a mouse model of acute spinal cord injury

Hee Kim Joong, David N. Loy, Hsiao Fang Liang, Kathryn Trinkaus, Robert E. Schmidt, Sheng Kwei Song

Research output: Contribution to journalArticle

135 Scopus citations

Abstract

We examined in vivo measurements of directional diffusivity derived from diffusion tensor imaging (DTI) to study the evolution of ventrolateral white matter (VWM) changes following contusive spinal cord injury (SCI) in C57BL/6 mice at 1, 3, 7, and 14 days postinjury. Relative anisotropy maps provided excellent gray matter (GM)/white matter (WM) contrast for characterization of evolving WM injury at all time points. Longitudinal DTI measurements clearly demonstrated rostral-caudal injury asymmetry. Axial diffusivity provided a sensitive, noninvasive measure of axonal integrity within the injury epicenter and at remote levels. Quantitative measurements of axial and radial diffusivities in VWM showed a trend of acute primary axonal injury followed by delayed, subacute myelin damage at the impact site, with good histological correlation.

Original languageEnglish
Pages (from-to)253-260
Number of pages8
JournalMagnetic resonance in medicine
Volume58
Issue number2
DOIs
StatePublished - Aug 2007

Keywords

  • Anisotropy
  • Axial
  • Contusion
  • Diffusion tensor imaging
  • Locomotion
  • Magnetic resonance
  • Mouse
  • Radial
  • Spinal cord injury

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