Noninvasive diagnosis of infection using plasma next-generation sequencing: A single-center experience

Jenna Rossoff; Sonali Chaudhury; Maulin Soneji; Sameer J. Patel; Soyang Kwon; Amy Armstrong; William J. Muller

doi:10.1093/ofid/ofz327

Noninvasive diagnosis of infection using plasma next-generation sequencing: A single-center experience

Jenna Rossoff, Sonali Chaudhury, Maulin Soneji, Sameer J. Patel, Soyang Kwon, Amy Armstrong, William J. Muller

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

Pediatric patients frequently present with illnesses strongly suggesting infection, but without a clearly identified etiology. Our center has recently added a commercially available plasma metagenomic sequencing assay to its available diagnostic testing. Our experience with the first 100 tests suggests that this technology has good clinical performance with >90% sensitivity.

Original language	English
Article number	ofz327
Journal	Open Forum Infectious Diseases
Volume	6
Issue number	8
DOIs	https://doi.org/10.1093/ofid/ofz327
State	Published - Jun 3 2019

Keywords

bacterial infection
metagenomic next-generation sequencing
viral infection

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10.1093/ofid/ofz327

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title = "Noninvasive diagnosis of infection using plasma next-generation sequencing: A single-center experience",

abstract = "Pediatric patients frequently present with illnesses strongly suggesting infection, but without a clearly identified etiology. Our center has recently added a commercially available plasma metagenomic sequencing assay to its available diagnostic testing. Our experience with the first 100 tests suggests that this technology has good clinical performance with >90% sensitivity.",

keywords = "bacterial infection, metagenomic next-generation sequencing, viral infection",

author = "Jenna Rossoff and Sonali Chaudhury and Maulin Soneji and Patel, {Sameer J.} and Soyang Kwon and Amy Armstrong and Muller, {William J.}",

note = "Publisher Copyright: {\textcopyright} 2019 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

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AU - Chaudhury, Sonali

AU - Soneji, Maulin

AU - Patel, Sameer J.

AU - Kwon, Soyang

AU - Armstrong, Amy

AU - Muller, William J.

PY - 2019/6/3

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AB - Pediatric patients frequently present with illnesses strongly suggesting infection, but without a clearly identified etiology. Our center has recently added a commercially available plasma metagenomic sequencing assay to its available diagnostic testing. Our experience with the first 100 tests suggests that this technology has good clinical performance with >90% sensitivity.

KW - bacterial infection

KW - metagenomic next-generation sequencing

KW - viral infection

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Noninvasive diagnosis of infection using plasma next-generation sequencing: A single-center experience

Abstract

Keywords

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