| Original language | English |
|---|---|
| Pages (from-to) | 884-887.e3 |
| Journal | Gastroenterology |
| Volume | 157 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 2019 |
Keywords
- Early Cancer Detection
- High-Risk Adenoma
- Precision Oncology
- Stool RNA
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}
In: Gastroenterology, Vol. 157, No. 3, 09.2019, p. 884-887.e3.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Noninvasive Detection of High-Risk Adenomas Using Stool-Derived Eukaryotic RNA Sequences as Biomarkers
AU - Geneoscopy Scientists
AU - Barnell, Erica K.
AU - Kang, Yiming
AU - Wurtzler, Elizabeth M.
AU - Griffith, Malachi
AU - Chaudhuri, Aadel A.
AU - Griffith, Obi L.
AU - Barnell, Andrew R.
AU - Campbell, Katie M.
AU - Kruse, Kimberly R.
AU - Messina, Dave
AU - Kodner, Ira
AU - Manary, Mark
AU - Needleman, Phil
N1 - Funding Information: Funding This research was funded by Geneoscopy LLC (St Louis, MO), which is a startup company developed from technology at the Washington University School of Medicine and grants from Accelerate St Louis, Arch Grants, BioGenerator Labs, The Global Impact Award, and The Wharton School. Malachi Griffith is supported by the National Human Genome Research Institute under award number K99HG007940. Aadel A. Chaudhuri is supported by the National Cancer Institute (NCI) under award number K08CA238711, the Washington University Pancreas SPORE Career Enhancement Program under grant number P50CA196510 from the NCI, and the Cancer Research Foundation Young Investigator Award. Obi L. Griffith is supported by the NCI under award number K22CA188163. The content of this manuscript is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This work would not have been possible without the dedication and commitment of the Geneoscopy Scientists: Andrew R. Barnell, Division of Gastroenterology and Hepatology, Geneoscopy LLC, St Louis, Missouri; Katie M. Campbell, McDonnell Genome Institute, Washington University School of Medicine, St Louis, Missouri and Division of Gastroenterology and Hepatology, Geneoscopy LLC, St Louis, Missouri; and Kimberly R. Kruse, Division of Gastroenterology and Hepatology, Geneoscopy LLC, St Louis, Missouri. We would like to thank our scientific advisors: Dave Messina, Ira Kodner, Mark Manary, and Phil Needleman. This research would not have been possible without the support and assistance of Accelerate St. Louis, Arch Grants, BioSTL, BioGenerator Labs, Sling Health St. Louis, The Global Impact Award, The Skandalaris Center, Cofactor Genomics, The Wharton School, and Washington University School of Medicine. Author contributions: EKB and YK contributed to the study concept and design. EKB, YK, ARB, KMC, and EMW contributed to the acquisition, analysis, and interpretation of data. EKB, YK, ARB, KMC, KRK, and EMW contributed to drafting of the manuscript. MG, AAC, and OLG contributed to critical revision of the manuscript. EKB, YK, ARB, and KMC contributed to statistical analysis. EKB, YK, and ARB obtained funding. MG, AAC, and OLG contributed to study supervision. All authors have seen and approved the final draft.
PY - 2019/9
Y1 - 2019/9
KW - Early Cancer Detection
KW - High-Risk Adenoma
KW - Precision Oncology
KW - Stool RNA
UR - http://www.scopus.com/inward/record.url?scp=85070751065&partnerID=8YFLogxK
U2 - 10.1053/j.gastro.2019.05.058
DO - 10.1053/j.gastro.2019.05.058
M3 - Article
C2 - 31154021
AN - SCOPUS:85070751065
SN - 0016-5085
VL - 157
SP - 884-887.e3
JO - Gastroenterology
JF - Gastroenterology
IS - 3
ER -