Noninvasive delineation of the effects of moderate aging on myocardial perfusion

M. J. Senneff, E. M. Geltman, S. R. Bergmann, J. Hartman

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63 Scopus citations


Aging is accompanied by a decline in many aspects of cardiovascular function but little is known regarding its influence on myocardial perfusion. Eleven young adults (mean age 25 ± 4 (s.d.) yr) and 15 older adults (mean age 55 ± 9 yr) without history or symptoms of cardiovascular disease were studied using H215O and positron emission tomography under resting conditions and following administration of intravenous dipyridamole. Myocardial perfusion at rest was similar in the older and younger subjects, averaging 1.17 ± 0.35 and 1.16 ± 0.32 ml/g/min, respectively (p = ns). Following dipyridamole, peak myocardial perfusion was blunted in the older subjects, averaging 3.12 ± 1.09 ml/g/min compared with 4.25 ± 1.54 ml/g/min in the young adults (p = 0.044). Accordingly, present standards for normal perfusion responses to intravenous dipyridamole may require adjustment for age.

Original languageEnglish
Pages (from-to)2037-2042
Number of pages6
JournalJournal of Nuclear Medicine
Issue number11
StatePublished - 1991


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