Nonenzymatic dynamic kinetic resolution of α-(arylthio)- and α-(alkylthio)alkanoic acids

Xing Yang; Vladimir B. Birman

doi:10.1002/anie.201007860

Nonenzymatic dynamic kinetic resolution of α-(arylthio)- and α-(alkylthio)alkanoic acids

Xing Yang
, Vladimir B. Birman

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Dynamic solution: The title acids undergo dynamic kinetic resolution during an enantioselective esterification catalyzed by (S)-homobenzotetramisole ((S)-HBTM; see scheme). This method extends the scope of the carboxylic acid derivatives that are amenable to the nonenzymatic version of this transformation.

Original language	English
Pages (from-to)	5553-5555
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	24
DOIs	https://doi.org/10.1002/anie.201007860
State	Published - Jun 6 2011

Keywords

acyl-transfer catalysis
kinetic resolution
organocatalysis
racemization
synthetic methods

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10.1002/anie.201007860

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title = "Nonenzymatic dynamic kinetic resolution of α-(arylthio)- and α-(alkylthio)alkanoic acids",

abstract = "Dynamic solution: The title acids undergo dynamic kinetic resolution during an enantioselective esterification catalyzed by (S)-homobenzotetramisole ((S)-HBTM; see scheme). This method extends the scope of the carboxylic acid derivatives that are amenable to the nonenzymatic version of this transformation.",

keywords = "acyl-transfer catalysis, kinetic resolution, organocatalysis, racemization, synthetic methods",

author = "Xing Yang and Birman, \{Vladimir B.\}",

year = "2011",

month = jun,

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doi = "10.1002/anie.201007860",

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journal = "Angewandte Chemie - International Edition",

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T1 - Nonenzymatic dynamic kinetic resolution of α-(arylthio)- and α-(alkylthio)alkanoic acids

AU - Yang, Xing

AU - Birman, Vladimir B.

PY - 2011/6/6

Y1 - 2011/6/6

N2 - Dynamic solution: The title acids undergo dynamic kinetic resolution during an enantioselective esterification catalyzed by (S)-homobenzotetramisole ((S)-HBTM; see scheme). This method extends the scope of the carboxylic acid derivatives that are amenable to the nonenzymatic version of this transformation.

AB - Dynamic solution: The title acids undergo dynamic kinetic resolution during an enantioselective esterification catalyzed by (S)-homobenzotetramisole ((S)-HBTM; see scheme). This method extends the scope of the carboxylic acid derivatives that are amenable to the nonenzymatic version of this transformation.

KW - acyl-transfer catalysis

KW - kinetic resolution

KW - organocatalysis

KW - racemization

KW - synthetic methods

UR - https://www.scopus.com/pages/publications/79958028870

U2 - 10.1002/anie.201007860

DO - 10.1002/anie.201007860

M3 - Article

C2 - 21538734

AN - SCOPUS:79958028870

SN - 1433-7851

VL - 50

SP - 5553

EP - 5555

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 24

ER -

Nonenzymatic dynamic kinetic resolution of α-(arylthio)- and α-(alkylthio)alkanoic acids

Abstract

Keywords

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