Nonenzymatic dynamic kinetic resolution of α-(arylthio)- and α-(alkylthio)alkanoic acids

Xing Yang, Vladimir B. Birman

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Dynamic solution: The title acids undergo dynamic kinetic resolution during an enantioselective esterification catalyzed by (S)-homobenzotetramisole ((S)-HBTM; see scheme). This method extends the scope of the carboxylic acid derivatives that are amenable to the nonenzymatic version of this transformation.

Original languageEnglish
Pages (from-to)5553-5555
Number of pages3
JournalAngewandte Chemie - International Edition
Volume50
Issue number24
DOIs
StatePublished - Jun 6 2011

Keywords

  • acyl-transfer catalysis
  • kinetic resolution
  • organocatalysis
  • racemization
  • synthetic methods

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