Noncanonical views of homology-directed DNA repair

Priyanka Verma, Roger A. Greenberg

Research output: Contribution to journalReview articlepeer-review

87 Scopus citations

Abstract

DNArepair is essential to maintain genomic integrity and initiate genetic diversity. While gene conversion and classical nonhomologous end-joining are the most physiologically predominant forms of DNA repair mechanisms, emerging lines of evidence suggest the usage of several noncanonical homology-directed repair (HDR) pathways in both prokaryotes and eukaryotes in different contexts. Here we review how these alternative HDR pathways are executed, specifically focusing on the determinants that dictate competition between them and their relevance to cancers that display complex genomic rearrangements or maintain their telomeres by homology-directed DNA synthesis.

Original languageEnglish
Pages (from-to)1138-1154
Number of pages17
JournalGenes and Development
Volume30
Issue number10
DOIs
StatePublished - May 15 2016

Keywords

  • ALT
  • Break-induced replication
  • DNA repair
  • Homologous recombination
  • Telomere

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