Nonalcoholic fatty liver disease: MR imaging of liver proton density fat fraction to assess hepatic steatosis

An Tang, Justin Tan, Mark Sun, Gavin Hamilton, Mark Bydder, Tanya Wolfson, Anthony C. Gamst, Michael Middleton, Elizabeth M. Brunt, Rohit Loomba, Joel E. Lavine, Jeffrey B. Schwimmer, Claude B. Sirlin

Research output: Contribution to journalArticlepeer-review

303 Scopus citations


Purpose: To evaluate the diagnostic performance of magnetic resonance (MR) imaging-estimated proton density fat fraction (PDFF) for assessing hepatic steatosis in nonalcoholic fatty liver disease (NAFLD) by using centrally scored histopathologic validation as the reference standard. Materials and Methods: This prospectively designed, cross-sectional, internal review board-approved, HIPAA-compliant study was conducted in 77 patients who had NAFLD and liver biopsy. MR imaging-PDFF was estimated from magnitude-based low flip angle multiecho gradient-recalled echo images after T2 correction and multifrequency fat modeling. Histopathologic scoring was obtained by consensus of the Nonalcoholic Steatohepatitis (NASH) Clinical Research Network Pathology Committee. Spearman correlation, additivity and variance stabilization for regression for exploring the effect of a number of potential confounders, and receiver operating characteristic analyses were performed. Results: Liver MR imaging-PDFF was systematically higher, with higher histologic steatosis grade (P <.001), and was significantly correlated with histologic steatosis grade (r = 0.69, P<.001). The correlation was not confounded by age, sex, lobular inflammation, hepatocellular ballooning, NASH diagnosis, fibrosis, or magnetic field strength (P = .65). Area under the receiver operating characteristic curves was 0.989 (95% confidence interval: 0.968, 1.000) for distinguishing patients with steatosis grade 0 (n = 5) from those with grade 1 or higher (n = 72), 0.825 (95% confidence interval: 0.734, 0.915) to distinguish those with grade 1 or lower (n = 31) from those with grade 2 or higher (n = 46), and 0.893 (95% confidence interval: 0.809, 0.977) to distinguish those with grade 2 or lower (n = 58) from those with grade 3 (n = 19). Conclusion: MR imaging-PDFF showed promise for assessment of hepatic steatosis grade in patients with NAFLD. For validation, further studies with larger sample sizes are needed.

Original languageEnglish
Pages (from-to)422-431
Number of pages10
Issue number2
StatePublished - May 2013


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