TY - JOUR
T1 - Non-steroidal anti-inflammatory drugs use is associated with reduced risk of inflammation-associated cancers
T2 - NIH-AARP study
AU - Shebl, Fatma M.
AU - Hsing, Ann W.
AU - Park, Yikyung
AU - Hollenbeck, Albert R.
AU - Chu, Lisa W.
AU - Meyer, Tamra E.
AU - Koshiol, Jill
N1 - Funding Information:
This research was supported by the Intramural Research Program of the NIH, National Cancer Institute. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. In memory of Dr. Arthur Schatzkin, visionary investigator who founded the NIHAARP Diet and Health Study. We are grateful to the participants in the NIH-AARP Diet and Health Study for their cooperation. For study outcomes ascertainment and management, we thank Kerry Grace Morrissey and Sigurd Hermansen Westat, in addition, we thank Leslie Carroll at Information Management Services for data support. This research was supported by the Intramural Research Program of the NIH, National Cancer Institute. The Georgia Center for Cancer Statistics, Department of Epidemiology, Rollins School of Public Health, Emory University collected cancer incidence data from the Atlanta metropolitan area. Cancer incidence data from California were collected by the California Department of Health Services, Cancer Surveillance Section. The Michigan Cancer Surveillance Program, Community Health Administration, State of Michigan collected cancer incidence data from the Detroit metropolitan area. The Florida cancer incidence data used in this report were collected by the Florida Cancer Data System (FCDC) under contract with the Florida Department of Health (FDOH). Cancer incidence data from Louisiana were collected by the Louisiana Tumor Registry, Louisiana State University Medical Center in New Orleans. Cancer incidence data from New Jersey were collected by the New Jersey State Cancer Registry, Cancer Epidemiology Services, New Jersey State Department of Health and Senior Services. Cancer incidence data from North Carolina were collected by the North Carolina Central Cancer Registry. Cancer incidence data from Pennsylvania were supplied by the Division of Health Statistics and Research, Pennsylvania Department of Health, Harrisburg, Pennsylvania. Cancer incidence data from Arizona were collected by the Arizona Cancer Registry, Division of Public Health Services, Arizona Department of Health Services. Cancer incidence data from Texas were collected by the Texas Cancer Registry, Cancer Epidemiology and Surveillance Branch, Texas Department of State Health Services. Cancer incidence data from Nevada were collected by the Nevada Central Cancer Registry, Center for Health Data and Research, Bureau of Health Planning and Statistics, State Health Division, State of Nevada Department of Health and Human Services. The views expressed herein are solely those of the authors and do not necessarily reflect those of the NIH-AARP.
PY - 2014/12
Y1 - 2014/12
N2 - Background: Chronic inflammation has been linked to cancers, and use of nonsteroidal anti-inflammatory drugs (NSAIDs) has been associated with reduced risk of several cancers. To further refine the magnitude of NSAID-related associations, in particular for cancers related to inflammation, such as alcohol-, infection-, obesity-, and smoking-related cancers, as well as for less common cancers, we evaluated the use of NSAIDs and cancer risk in a very large cohort. We used propensity scores to account for potential selection bias and hypothesized that NSAID use is associated with decreased cancer incidence. Methods: We conducted a prospective study among 314,522 participants in the NIH-AARP Diet and Health Study. Individuals who completed the lifestyle questionnaire, which included NSAID use, in 1996-1997 were followed through 2006. Information on cancer incidence was ascertained by linking to cancer registries and vital status databases. Findings: During 2,715,994 person-years of follow-up (median 10.1 person-years), there were 51,894 incident cancers. Compared with non-users of NSAIDs, individuals who reported use in the 12 months prior to interview had a significantly lower risk of all inflammation-related cancer, alcohol-related, infection-related, obesity-related, and smoking-related cancers [hazard ratio (HR) (95% CI)) 0.90 (0.87-0.93), 0.80 (0.74-0.85), 0.82 (0.78-0.87), 0.88 (0.84-0.92), and 0.88 (0.85- 0.92) respectively)]. Conclusions: After accounting for potential selection bias, our data showed an inverse association between NSAID use and alcohol-related, infection-related, obesity-related, and smoking-related cancers and support the hypothesis that inflammation is related to an increased risk of certain cancers.
AB - Background: Chronic inflammation has been linked to cancers, and use of nonsteroidal anti-inflammatory drugs (NSAIDs) has been associated with reduced risk of several cancers. To further refine the magnitude of NSAID-related associations, in particular for cancers related to inflammation, such as alcohol-, infection-, obesity-, and smoking-related cancers, as well as for less common cancers, we evaluated the use of NSAIDs and cancer risk in a very large cohort. We used propensity scores to account for potential selection bias and hypothesized that NSAID use is associated with decreased cancer incidence. Methods: We conducted a prospective study among 314,522 participants in the NIH-AARP Diet and Health Study. Individuals who completed the lifestyle questionnaire, which included NSAID use, in 1996-1997 were followed through 2006. Information on cancer incidence was ascertained by linking to cancer registries and vital status databases. Findings: During 2,715,994 person-years of follow-up (median 10.1 person-years), there were 51,894 incident cancers. Compared with non-users of NSAIDs, individuals who reported use in the 12 months prior to interview had a significantly lower risk of all inflammation-related cancer, alcohol-related, infection-related, obesity-related, and smoking-related cancers [hazard ratio (HR) (95% CI)) 0.90 (0.87-0.93), 0.80 (0.74-0.85), 0.82 (0.78-0.87), 0.88 (0.84-0.92), and 0.88 (0.85- 0.92) respectively)]. Conclusions: After accounting for potential selection bias, our data showed an inverse association between NSAID use and alcohol-related, infection-related, obesity-related, and smoking-related cancers and support the hypothesis that inflammation is related to an increased risk of certain cancers.
UR - http://www.scopus.com/inward/record.url?scp=84928568621&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0114633
DO - 10.1371/journal.pone.0114633
M3 - Article
C2 - 25551641
AN - SCOPUS:84928568621
SN - 1932-6203
VL - 9
JO - PloS one
JF - PloS one
IS - 12
M1 - e114633
ER -