TY - JOUR
T1 - Non-model model organisms
AU - Russell, James J.
AU - Theriot, Julie A.
AU - Sood, Pranidhi
AU - Marshall, Wallace F.
AU - Landweber, Laura F.
AU - Fritz-Laylin, Lillian
AU - Polka, Jessica K.
AU - Oliferenko, Snezhana
AU - Gerbich, Therese
AU - Gladfelter, Amy
AU - Umen, James
AU - Bezanilla, Magdalena
AU - Lancaster, Madeline A.
AU - He, Shuonan
AU - Gibson, Matthew C.
AU - Goldstein, Bob
AU - Tanaka, Elly M.
AU - Hu, Chi Kuo
AU - Brunet, Anne
N1 - Funding Information:
J.J.R. and J.A.T.: Our research on diatoms is supported by a grant from the Gordon and Betty Moore Foundation. P.S. and W.F.M. acknowledge the support of an American Cancer Society postdoctoral fellowship (PS) and NIH grant R01 GM113602. L.F.L. thanks Tom Doak and Michael Lu for comments on the size of the macronucleus. L. F-L.: I would like to thank Zac Cande and Scott Dawson for introducing me to Naegleria, and Chandler Fulton for teaching me nearly everything I know about our “wee friend.” Thanks Chan! J.K.P.: I would like to thank Pamela Silver for her support. S.O.: I am grateful to E. Makeyev for suggestions on the manuscript, M. Makarova for the microscopy image, and Y. Gu for help with artwork. Our work is supported by a Wellcome Trust Senior Investigator Award (103741/Z/ 14/Z) to S.O. T.G. and A.G.: We thank Anum Khan and Molly McQuilken for providing images for Fig. 7. J.U.: I thank Gavriel Matt for comments on this article and for photomicrographs. Work in my laboratory is supported by National Science Foundation grants MCB 1515220 and MCB 1616820. M.B.: Thank you to Shu-Zon Wu who took the images in Fig. 9. I would also like to thank the Bezanilla lab for reading the document and Ana Maria Bezanilla for artistic advice. This was supported by a grant from the NSF to MB (MCB-1330171) and summer research fellowships from the Marine Biological Laboratory. M.A.L. would like to thank members of the Lancaster laboratory for helpful comments. Work in the Lancaster laboratory is supported by the Medical Research Council MC_UP_1201/9, and a 3Rs prize from the National Centre for the Replacement, Refinement and Reduction of Animals in Research. S.H. and M.C.G: We thank Whitney J. Fropf from the Gibson lab for proofreading the manuscript. We also appreciate the helpful discussion all Gibson lab members provided during the writing of this review. B.G.: Thanks to current and former lab members for brainstorming and for discoveries, and to the NSF for taking a risk in funding work on an unusual model. Water bear work in the lab has been supported by NSF grants IOS 1557432, IOS 1257320, and IOS 0235658. E.M.T.: I would like to thank all the lab members and animal technicians who have worked in our lab over the years C-K.H. and A.B.: We thank all members in the Brunet lab for helpful input and discussion. This work was supported by the National Institutes of Health (NIH) DP1AG044848 and the Glenn Laboratories for the Biology of Aging (A.B.) and by the NIH T32 Cancer Biology Training Grant (5 T32 CA 9302-35) and the Life Science Research Foundation fellowships (C-K.H).
Publisher Copyright:
© 2017 Marshall et al.
PY - 2017/6/29
Y1 - 2017/6/29
N2 - Model organisms are widely used in research as accessible and convenient systems to study a particular area or question in biology. Traditionally only a handful of organisms have been widely studied, but modern research tools are enabling researchers to extend the set of model organisms to include less-studied and more unusual systems. This Forum highlights a range of 'non-model model organisms' as emerging systems for tackling questions across the whole spectrum of biology (and beyond), the opportunities and challenges, and the outlook for the future.
AB - Model organisms are widely used in research as accessible and convenient systems to study a particular area or question in biology. Traditionally only a handful of organisms have been widely studied, but modern research tools are enabling researchers to extend the set of model organisms to include less-studied and more unusual systems. This Forum highlights a range of 'non-model model organisms' as emerging systems for tackling questions across the whole spectrum of biology (and beyond), the opportunities and challenges, and the outlook for the future.
UR - http://www.scopus.com/inward/record.url?scp=85021381312&partnerID=8YFLogxK
U2 - 10.1186/s12915-017-0391-5
DO - 10.1186/s12915-017-0391-5
M3 - Article
C2 - 28662661
AN - SCOPUS:85021381312
SN - 1741-7007
VL - 15
JO - BMC Biology
JF - BMC Biology
IS - 1
M1 - 55
ER -