Non-immunologic allograft loss in pediatric kidney transplant recipients

Isa F. Ashoor, Vikas R. Dharnidharka

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Non-immunologic risk factors are a major obstacle to realizing long-term improvements in kidney allograft survival. A standardized approach to assess donor quality has recently been introduced with the new kidney allocation system in the USA. Delayed graft function and surgical complications are important risk factors for both short- and long-term graft loss. Disease recurrence in the allograft remains a major cause of graft loss in those who fail to respond to therapy. Complications of over immunosuppression including opportunistic infections and malignancy continue to limit graft survival. Alternative immunosuppression strategies are under investigation to limit calcineurin inhibitor toxicity. Finally, recent studies have confirmed long-standing observations of the significant negative impact of a high-risk age window in late adolescence and young adulthood on long-term allograft survival.

Original languageEnglish
Pages (from-to)211-222
Number of pages12
JournalPediatric Nephrology
Volume34
Issue number2
DOIs
StatePublished - Feb 1 2019

Keywords

  • Allograft dysfunction
  • BKV nephropathy
  • Calcineurin inhibitors
  • Disease recurrence
  • Kidney transplant
  • Non-adherence

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