Abstract
Background: Infective endocarditis caused by non-HACEK (species other than Haemophilus species, Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, or Kingella species) gram-negative bacilli is rare, is poorly characterized, and is commonly considered to be primarily a disease of injection drug users. Objective: To describe the clinical characteristics and outcomes of patients with non-HACEK gram-negative bacillus endocarditis in a large, international, contemporary cohort of patients. Design: Observations from the International Collaboration on Infective Endocarditis Prospective Cohort Study (ICE-PCS) database. Setting: 61 hospitals in 28 countries. Patients: Hospitalized patients with definite endocarditis. Measurements: Characteristics of non-HACEK gram-negative bacillus endocarditis cases were described and compared with those due to other pathogens. Results: Among the 2761 case-patients with definite endocarditis enrolled in ICE-PCS, 49 (1.8%) had endocarditis (20 native valve, 29 prosthetic valve or device) due to non-HACEK, gram-negative bacilli. Escherichia coli (14 patients [29%]) and Pseudomonas aeruginosa (11 patients [22%]) were the most common pathogens. Most patients (57%) with non-HACEK gram-negative bacillus endocarditis had health care-associated infection, whereas injection drug use was rare (4%). Implanted endovascular devices were frequently associated with non-HACEK gram-negative bacillus endocarditis compared with other causes of endocarditis (29% vs. 11%; P < 0.001). The in-hospital mortality rate of patients with endocarditis due to non-HACEK gram-negative bacilli was high (24%) despite high rates of cardiac surgery (51%). Limitations: Because of the small number of patients with non-HACEK gram-negative bacillus endocarditis in each treatment group and the lack of long-term follow-up, strong treatment recommendations are difficult to make. Conclusion: In this large, prospective, multinational cohort, more than one half of all cases of non-HACEK gram-negative bacillus endocarditis were associated with health care contact. Non-HACEK gram-negative bacillus endocarditis is not primarily a disease of injection drug users.
| Original language | English |
|---|---|
| Pages (from-to) | 829-835 |
| Number of pages | 7 |
| Journal | Annals of internal medicine |
| Volume | 147 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 18 2007 |
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Non-HACEK gram-negative bacillus endocarditis. / Morpeth, Susan; Murdoch, David; Cabell, Christopher H.; Karchmer, Adolf W.; Pappas, Paul; Levine, Donald; Nacinovich, Francisco; Tattevin, Pierre; Fernández-Hidalgo, Núria; Dickerman, Stuart; Bouza, Emilio; Del Río, Ana; Lejko-Zupanc, Tatjana; De Oliveira Ramos, Auristela; Iarussi, Diana; Klein, John; Chirouze, Catherine; Bedimo, Roger; Corey, G. Ralph; Fowler, Vance G.; Gordon, David; Devi, Uma; Spelman, Denis; Van Der Meer, Jan T.M.; Kauffman, Carol; Bradley, Suzanne; Armstrong, William; Giannitsioti, Efthymia; Giamarellou, Helen; Lerakis, Stamatios; Moreno, Asuncion; Mestres, Carlos A.; Paré, Carlos; Garcia De La Maria, Cristina; De Lazzario, Elisa; Marco, Francesc; Gatell, Jose M.; Miró, José M.; Almela, Manel; Azqueta, Manuel; Jiménez-Expósito, Maria Jesús; De Benito, Natividad; Perez, Noel; Almirante, Benito; Rodriguez De Vera, Pablo; Tornos, Pilar; Falcó, Vicente; Claramonte, Xavier; Armero, Yolanda; Sidani, Nisreen; Kanj-Sharara, Souha; Kanafani, Zeina; Raglio, Annibale; Goglio, Antonio; Gnecchi, Fabrizio; Suter, Fredy; Valsecchi, Grazia; Rizzi, Marco; Ravasio, Veronica; Hoen, Bruno; Leroy, Joel; Plesiat, Patrick; Bernard, Yvette; Casey, Anna; Lambert, Peter; Watkin, Richard; Elliott, Tom; Patel, Mukesh; Dismukes, William; Pan, Angelo; Caros, Giampiero; Tribouilloy, Amel Brahim Mathiron Christophe; Goissen, Thomas; Delahaye, Armelle; Delahaye, Francois; Vandenesch, Francois; Vizzotti, Carla; Nacinovich, Francisco M.; Marin, Marcelo; Trivi, Marcelo; Lombardero, Martin; Cortes, Claudia; Casabé, José Horacio; Altclas, Javier; Kogan, Silvia; Clara, Liliana; Sanchez, Marisa; Commerford, Anita; Hansa, Cass; Deetlefs, Eduan; Ntsekhe, Mpiko; Commerford, Patrick; Wray, Dannah; Steed, Lisa L.; Church, Preston; Cantey, Robert; Morris, Arthur; Chambers, Stephen; Read, Kerry; Raymond, Nigel; Holland, David; Lang, Selwyn; Kotsanas, Despina; Korman, Tony M.; Peterson, Gail; Purcell, Jon; Southern, Paul M.; Shah, Manisha; Reddy, Arjun; Dhar, Gaurav; Hanlon-Feeney, Alanna; Hannan, Margaret; Kelly, Sinead; Wang, Andrew; Woods, Christopher W.; Sexton, Daniel J.; Benjamin, Danny; McDonald, Jay R.; Federspiel, Jeff; Engemann, John J.; Reller, L. Barth; Drew, Laura; Caram, L. B.; Stryjewski, Martin; Lalani, Tahaniyat; Chu, Vivian; Mazaheri, Bahram; Neuerburg, Carl; Naber, Christoph; Athan, Eugene; Henry, Margaret; Harris, Owen; Alestig, Eric; Olaison, Lars; Wikstrom, Lotta; Snygg-Martin, Ulrika; Francis, Johnson; Venugopal, K.; Nair, Lathi; Thomas, Vinod; Chaiworramukkun, Jaruwan; Pachirat, Orathai; Chetchotisakd, Ploenchan; Suwanich, Tewan; Kamarulzaman, Adeeba; Tamin, Syahidah Syed; Mueller Premru, Manica; Logar, Mateja; Orezzi, Christina; Moreno, Mar; Rodríguez-Créixems, Marta; Marín, Mercedes; Fernández, Miguel; Muñoz, Patricia; Fernández, Rocío; Ramallo, Victor; Raoult, Didier; Thuny, Franck; Habib, Gilbert; Casalta, Jean Paul; Fournier, Pierre Edouard; Chipigina, Natalia; Kirill, Ozerecky; Vinogradova, Tatiana; Kulichenko, Vadim P.; Butkevich, O. M.; Lion, Christine; Selton-Suty, Christine; Alla, Francois; Coyard, Hélène; Doco-Lecompte, Thanh; Durante-Mangoni, Emanuele; Ragone, Enrico; Dialetto, Giovanni; Tripodi, Marie Françoise; Utili, Riccardo; Casillo, Roberta; Kumar, A. Sampath; Sharma, Gautam; Street, Alan; Eisen, Damon Peter; McBryde, Emma Sue; Grigg, Leeanne; Abrutyn, Elias; Michelet, Christian; Donnio, Pierre Yves; Fortes, Claudio Querido; Edathodu, Jameela; Al-Hegelan, Mashael; Font, Bernat; Anguera, Ignasi; Guma, Joan Raimon; Cereceda, M.; Oyonarte, Miguel J.; Mella, Rodrigo Montagna; Garcia, Patricia; Jones, Sandra Braun; Paiva, Marcelo Goulart; Tranchesi, Regina Aparecida De Medeiros; Woon, Lok Ley; Lum, Luh Nah; Tan, Ru San; Rees, David; Kornecny, Pam; Lawrence, Richard; Dever, Robyn; Post, Jeffrey; Jones, Phillip; Ryan, Suzanne; Harkness, John; Feneley, Michael; Rubinstein, Ethan; Strahilewitz, Jacob; Ionac, Adina; Mornos, Cristian; Dragulescu, Stefan; Forno, Davide; Cecchi, Enrico; De Rosa, Francesco; Imazio, Massimo; Trinchero, Rita; Wiesbauer, Franz; Gattringer, Rainer; Deans, Greg; Andrasevic, Arjana Tambic; Barsic, Bruno; Klinar, Igor; Vincelj, Josip; Bukovski, Suzana; Krajinovic, Vladimir; Stafford, Judy; Baloch, Khaula; Redick, Thomas; Harding, Tina; Bayer, Arnold S.; Durack, David T.; Moreillon, Phillipe; Eykyn, Susannah.
In: Annals of internal medicine, Vol. 147, No. 12, 18.12.2007, p. 829-835.Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Non-HACEK gram-negative bacillus endocarditis
AU - Morpeth, Susan
AU - Murdoch, David
AU - Cabell, Christopher H.
AU - Karchmer, Adolf W.
AU - Pappas, Paul
AU - Levine, Donald
AU - Nacinovich, Francisco
AU - Tattevin, Pierre
AU - Fernández-Hidalgo, Núria
AU - Dickerman, Stuart
AU - Bouza, Emilio
AU - Del Río, Ana
AU - Lejko-Zupanc, Tatjana
AU - De Oliveira Ramos, Auristela
AU - Iarussi, Diana
AU - Klein, John
AU - Chirouze, Catherine
AU - Bedimo, Roger
AU - Corey, G. Ralph
AU - Fowler, Vance G.
AU - Gordon, David
AU - Devi, Uma
AU - Spelman, Denis
AU - Van Der Meer, Jan T.M.
AU - Kauffman, Carol
AU - Bradley, Suzanne
AU - Armstrong, William
AU - Giannitsioti, Efthymia
AU - Giamarellou, Helen
AU - Lerakis, Stamatios
AU - Moreno, Asuncion
AU - Mestres, Carlos A.
AU - Paré, Carlos
AU - Garcia De La Maria, Cristina
AU - De Lazzario, Elisa
AU - Marco, Francesc
AU - Gatell, Jose M.
AU - Miró, José M.
AU - Almela, Manel
AU - Azqueta, Manuel
AU - Jiménez-Expósito, Maria Jesús
AU - De Benito, Natividad
AU - Perez, Noel
AU - Almirante, Benito
AU - Rodriguez De Vera, Pablo
AU - Tornos, Pilar
AU - Falcó, Vicente
AU - Claramonte, Xavier
AU - Armero, Yolanda
AU - Sidani, Nisreen
AU - Kanj-Sharara, Souha
AU - Kanafani, Zeina
AU - Raglio, Annibale
AU - Goglio, Antonio
AU - Gnecchi, Fabrizio
AU - Suter, Fredy
AU - Valsecchi, Grazia
AU - Rizzi, Marco
AU - Ravasio, Veronica
AU - Hoen, Bruno
AU - Leroy, Joel
AU - Plesiat, Patrick
AU - Bernard, Yvette
AU - Casey, Anna
AU - Lambert, Peter
AU - Watkin, Richard
AU - Elliott, Tom
AU - Patel, Mukesh
AU - Dismukes, William
AU - Pan, Angelo
AU - Caros, Giampiero
AU - Tribouilloy, Amel Brahim Mathiron Christophe
AU - Goissen, Thomas
AU - Delahaye, Armelle
AU - Delahaye, Francois
AU - Vandenesch, Francois
AU - Vizzotti, Carla
AU - Nacinovich, Francisco M.
AU - Marin, Marcelo
AU - Trivi, Marcelo
AU - Lombardero, Martin
AU - Cortes, Claudia
AU - Casabé, José Horacio
AU - Altclas, Javier
AU - Kogan, Silvia
AU - Clara, Liliana
AU - Sanchez, Marisa
AU - Commerford, Anita
AU - Hansa, Cass
AU - Deetlefs, Eduan
AU - Ntsekhe, Mpiko
AU - Commerford, Patrick
AU - Wray, Dannah
AU - Steed, Lisa L.
AU - Church, Preston
AU - Cantey, Robert
AU - Morris, Arthur
AU - Chambers, Stephen
AU - Read, Kerry
AU - Raymond, Nigel
AU - Holland, David
AU - Lang, Selwyn
AU - Kotsanas, Despina
AU - Korman, Tony M.
AU - Peterson, Gail
AU - Purcell, Jon
AU - Southern, Paul M.
AU - Shah, Manisha
AU - Reddy, Arjun
AU - Dhar, Gaurav
AU - Hanlon-Feeney, Alanna
AU - Hannan, Margaret
AU - Kelly, Sinead
AU - Wang, Andrew
AU - Woods, Christopher W.
AU - Sexton, Daniel J.
AU - Benjamin, Danny
AU - McDonald, Jay R.
AU - Federspiel, Jeff
AU - Engemann, John J.
AU - Reller, L. Barth
AU - Drew, Laura
AU - Caram, L. B.
AU - Stryjewski, Martin
AU - Lalani, Tahaniyat
AU - Chu, Vivian
AU - Mazaheri, Bahram
AU - Neuerburg, Carl
AU - Naber, Christoph
AU - Athan, Eugene
AU - Henry, Margaret
AU - Harris, Owen
AU - Alestig, Eric
AU - Olaison, Lars
AU - Wikstrom, Lotta
AU - Snygg-Martin, Ulrika
AU - Francis, Johnson
AU - Venugopal, K.
AU - Nair, Lathi
AU - Thomas, Vinod
AU - Chaiworramukkun, Jaruwan
AU - Pachirat, Orathai
AU - Chetchotisakd, Ploenchan
AU - Suwanich, Tewan
AU - Kamarulzaman, Adeeba
AU - Tamin, Syahidah Syed
AU - Mueller Premru, Manica
AU - Logar, Mateja
AU - Orezzi, Christina
AU - Moreno, Mar
AU - Rodríguez-Créixems, Marta
AU - Marín, Mercedes
AU - Fernández, Miguel
AU - Muñoz, Patricia
AU - Fernández, Rocío
AU - Ramallo, Victor
AU - Raoult, Didier
AU - Thuny, Franck
AU - Habib, Gilbert
AU - Casalta, Jean Paul
AU - Fournier, Pierre Edouard
AU - Chipigina, Natalia
AU - Kirill, Ozerecky
AU - Vinogradova, Tatiana
AU - Kulichenko, Vadim P.
AU - Butkevich, O. M.
AU - Lion, Christine
AU - Selton-Suty, Christine
AU - Alla, Francois
AU - Coyard, Hélène
AU - Doco-Lecompte, Thanh
AU - Durante-Mangoni, Emanuele
AU - Ragone, Enrico
AU - Dialetto, Giovanni
AU - Tripodi, Marie Françoise
AU - Utili, Riccardo
AU - Casillo, Roberta
AU - Kumar, A. Sampath
AU - Sharma, Gautam
AU - Street, Alan
AU - Eisen, Damon Peter
AU - McBryde, Emma Sue
AU - Grigg, Leeanne
AU - Abrutyn, Elias
AU - Michelet, Christian
AU - Donnio, Pierre Yves
AU - Fortes, Claudio Querido
AU - Edathodu, Jameela
AU - Al-Hegelan, Mashael
AU - Font, Bernat
AU - Anguera, Ignasi
AU - Guma, Joan Raimon
AU - Cereceda, M.
AU - Oyonarte, Miguel J.
AU - Mella, Rodrigo Montagna
AU - Garcia, Patricia
AU - Jones, Sandra Braun
AU - Paiva, Marcelo Goulart
AU - Tranchesi, Regina Aparecida De Medeiros
AU - Woon, Lok Ley
AU - Lum, Luh Nah
AU - Tan, Ru San
AU - Rees, David
AU - Kornecny, Pam
AU - Lawrence, Richard
AU - Dever, Robyn
AU - Post, Jeffrey
AU - Jones, Phillip
AU - Ryan, Suzanne
AU - Harkness, John
AU - Feneley, Michael
AU - Rubinstein, Ethan
AU - Strahilewitz, Jacob
AU - Ionac, Adina
AU - Mornos, Cristian
AU - Dragulescu, Stefan
AU - Forno, Davide
AU - Cecchi, Enrico
AU - De Rosa, Francesco
AU - Imazio, Massimo
AU - Trinchero, Rita
AU - Wiesbauer, Franz
AU - Gattringer, Rainer
AU - Deans, Greg
AU - Andrasevic, Arjana Tambic
AU - Barsic, Bruno
AU - Klinar, Igor
AU - Vincelj, Josip
AU - Bukovski, Suzana
AU - Krajinovic, Vladimir
AU - Stafford, Judy
AU - Baloch, Khaula
AU - Redick, Thomas
AU - Harding, Tina
AU - Bayer, Arnold S.
AU - Durack, David T.
AU - Moreillon, Phillipe
AU - Eykyn, Susannah
PY - 2007/12/18
Y1 - 2007/12/18
N2 - Background: Infective endocarditis caused by non-HACEK (species other than Haemophilus species, Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, or Kingella species) gram-negative bacilli is rare, is poorly characterized, and is commonly considered to be primarily a disease of injection drug users. Objective: To describe the clinical characteristics and outcomes of patients with non-HACEK gram-negative bacillus endocarditis in a large, international, contemporary cohort of patients. Design: Observations from the International Collaboration on Infective Endocarditis Prospective Cohort Study (ICE-PCS) database. Setting: 61 hospitals in 28 countries. Patients: Hospitalized patients with definite endocarditis. Measurements: Characteristics of non-HACEK gram-negative bacillus endocarditis cases were described and compared with those due to other pathogens. Results: Among the 2761 case-patients with definite endocarditis enrolled in ICE-PCS, 49 (1.8%) had endocarditis (20 native valve, 29 prosthetic valve or device) due to non-HACEK, gram-negative bacilli. Escherichia coli (14 patients [29%]) and Pseudomonas aeruginosa (11 patients [22%]) were the most common pathogens. Most patients (57%) with non-HACEK gram-negative bacillus endocarditis had health care-associated infection, whereas injection drug use was rare (4%). Implanted endovascular devices were frequently associated with non-HACEK gram-negative bacillus endocarditis compared with other causes of endocarditis (29% vs. 11%; P < 0.001). The in-hospital mortality rate of patients with endocarditis due to non-HACEK gram-negative bacilli was high (24%) despite high rates of cardiac surgery (51%). Limitations: Because of the small number of patients with non-HACEK gram-negative bacillus endocarditis in each treatment group and the lack of long-term follow-up, strong treatment recommendations are difficult to make. Conclusion: In this large, prospective, multinational cohort, more than one half of all cases of non-HACEK gram-negative bacillus endocarditis were associated with health care contact. Non-HACEK gram-negative bacillus endocarditis is not primarily a disease of injection drug users.
AB - Background: Infective endocarditis caused by non-HACEK (species other than Haemophilus species, Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, or Kingella species) gram-negative bacilli is rare, is poorly characterized, and is commonly considered to be primarily a disease of injection drug users. Objective: To describe the clinical characteristics and outcomes of patients with non-HACEK gram-negative bacillus endocarditis in a large, international, contemporary cohort of patients. Design: Observations from the International Collaboration on Infective Endocarditis Prospective Cohort Study (ICE-PCS) database. Setting: 61 hospitals in 28 countries. Patients: Hospitalized patients with definite endocarditis. Measurements: Characteristics of non-HACEK gram-negative bacillus endocarditis cases were described and compared with those due to other pathogens. Results: Among the 2761 case-patients with definite endocarditis enrolled in ICE-PCS, 49 (1.8%) had endocarditis (20 native valve, 29 prosthetic valve or device) due to non-HACEK, gram-negative bacilli. Escherichia coli (14 patients [29%]) and Pseudomonas aeruginosa (11 patients [22%]) were the most common pathogens. Most patients (57%) with non-HACEK gram-negative bacillus endocarditis had health care-associated infection, whereas injection drug use was rare (4%). Implanted endovascular devices were frequently associated with non-HACEK gram-negative bacillus endocarditis compared with other causes of endocarditis (29% vs. 11%; P < 0.001). The in-hospital mortality rate of patients with endocarditis due to non-HACEK gram-negative bacilli was high (24%) despite high rates of cardiac surgery (51%). Limitations: Because of the small number of patients with non-HACEK gram-negative bacillus endocarditis in each treatment group and the lack of long-term follow-up, strong treatment recommendations are difficult to make. Conclusion: In this large, prospective, multinational cohort, more than one half of all cases of non-HACEK gram-negative bacillus endocarditis were associated with health care contact. Non-HACEK gram-negative bacillus endocarditis is not primarily a disease of injection drug users.
UR - http://www.scopus.com/inward/record.url?scp=38449122050&partnerID=8YFLogxK
U2 - 10.7326/0003-4819-147-12-200712180-00002
DO - 10.7326/0003-4819-147-12-200712180-00002
M3 - Article
C2 - 18087053
AN - SCOPUS:38449122050
VL - 147
SP - 829
EP - 835
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
SN - 0003-4819
IS - 12
ER -