Non-cell Autonomous Degeneration: Role of Astrocytes in Neurodegenerative Diseases. Role of Astrocytes in Neurodegenerative Diseases.

Sarah E. Smith, Azad Bonni

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

Astrocytes, representing the most abundant glial cells in the central nervous system, regulate the development and function of neurons. Accumulating evidence suggests that astrocytes also play pivotal roles in the pathogenesis of neurodegenerative diseases, once thought to selectively afflict neurons. In response to disease or injury, astrocytes become reactive with profound morphological and transcriptomic alterations. Some changes in reactive astrocyte morphology and function are thought to be beneficial. Other responses in reactive astrocytes contribute to neuronal degeneration. In this chapter, we review evidence for astrocyte-dependent non-cell autonomous degeneration of neurons in Amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, Huntington's disease, and spinocerebellar ataxia type 7. We also highlight recent advances in our understanding of glial cell-intrinsic mechanisms that underlie neurodegenerative diseases. These studies are laying the foundation for development of novel therapies in the treatment of neurodegenerative diseases.

Original languageEnglish
Title of host publicationThe Molecular and Cellular Basis of Neurodegenerative Diseases
Subtitle of host publicationUnderlying Mechanisms
PublisherElsevier Inc.
Pages415-440
Number of pages26
ISBN (Electronic)9780128113059
ISBN (Print)9780128113042
DOIs
StatePublished - Apr 4 2018

Keywords

  • ALS
  • Alzheimer's
  • Astrocytes
  • Glial-dependent degeneration
  • Huntington's
  • Neurodegeneration
  • Parkinson's

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