No survival benefit in never-smoker never-drinker patients with oral cavity cancer

Emily Z. Yan; Benjamin M. Wahle; Erik R. Nakken; Smrithi Chidambaram; Kayla Getz; Wade L. Thorstad; Jose P. Zevallos; Angela L. Mazul

doi:10.1002/hed.27266

No survival benefit in never-smoker never-drinker patients with oral cavity cancer

Emily Z. Yan, Benjamin M. Wahle, Erik R. Nakken, Smrithi Chidambaram, Kayla Getz, Wade L. Thorstad, Jose P. Zevallos, Angela L. Mazul

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Background: Although strongly associated with tobacco and alcohol use, many oral cavity squamous cell carcinoma (OCSCC) cases occur in patients without exposure to either, known as “never-smoker, never-drinkers” (NSND). We aimed to compare clinical outcomes between NSND and tobacco/alcohol-exposed populations and to define demographic characteristics of NSND. Methods: We performed a retrospective, single-institution cohort study of 672 OCSCC patients. Cox models were used to estimate differences in overall survival (OS) and recurrence-free survival (RFS) between NSND and tobacco/alcohol-exposed patients while adjusting for confounders. Results: NSND represented 25.6% of our cohort and were older, more female, and more economically advantaged. Among NSND, oral tongue tumors dominated in younger patients, while alveolar ridge tumors dominated in elderly patients. Multivariate survival analysis revealed no differences in OS or RFS between NSND and tobacco/alcohol-exposed patients. Conclusion: When adjusted for independent biologic features, clinical outcomes in OCSCC are similar between NSND and tobacco/alcohol-exposed patients.

Original language	English
Pages (from-to)	567-577
Number of pages	11
Journal	Head and Neck
Volume	45
Issue number	3
DOIs	https://doi.org/10.1002/hed.27266
State	Published - Mar 2023

Keywords

alcohol
head and neck squamous cell carcinoma
never-smoker never-drinker
oral cavity squamous cell carcinoma
survival
tobacco

Access to Document

10.1002/hed.27266

Cite this

@article{eac397d40df34a1a96f91e78cd404a63,

title = "No survival benefit in never-smoker never-drinker patients with oral cavity cancer",

abstract = "Background: Although strongly associated with tobacco and alcohol use, many oral cavity squamous cell carcinoma (OCSCC) cases occur in patients without exposure to either, known as “never-smoker, never-drinkers” (NSND). We aimed to compare clinical outcomes between NSND and tobacco/alcohol-exposed populations and to define demographic characteristics of NSND. Methods: We performed a retrospective, single-institution cohort study of 672 OCSCC patients. Cox models were used to estimate differences in overall survival (OS) and recurrence-free survival (RFS) between NSND and tobacco/alcohol-exposed patients while adjusting for confounders. Results: NSND represented 25.6% of our cohort and were older, more female, and more economically advantaged. Among NSND, oral tongue tumors dominated in younger patients, while alveolar ridge tumors dominated in elderly patients. Multivariate survival analysis revealed no differences in OS or RFS between NSND and tobacco/alcohol-exposed patients. Conclusion: When adjusted for independent biologic features, clinical outcomes in OCSCC are similar between NSND and tobacco/alcohol-exposed patients.",

keywords = "alcohol, head and neck squamous cell carcinoma, never-smoker never-drinker, oral cavity squamous cell carcinoma, survival, tobacco",

author = "Yan, {Emily Z.} and Wahle, {Benjamin M.} and Nakken, {Erik R.} and Smrithi Chidambaram and Kayla Getz and Thorstad, {Wade L.} and Zevallos, {Jose P.} and Mazul, {Angela L.}",

note = "Publisher Copyright: {\textcopyright} 2022 Wiley Periodicals LLC.",

year = "2023",

month = mar,

doi = "10.1002/hed.27266",

language = "English",

volume = "45",

pages = "567--577",

journal = "Head and Neck",

issn = "1043-3074",

number = "3",

}

TY - JOUR

T1 - No survival benefit in never-smoker never-drinker patients with oral cavity cancer

AU - Yan, Emily Z.

AU - Wahle, Benjamin M.

AU - Nakken, Erik R.

AU - Chidambaram, Smrithi

AU - Getz, Kayla

AU - Thorstad, Wade L.

AU - Zevallos, Jose P.

AU - Mazul, Angela L.

PY - 2023/3

Y1 - 2023/3

N2 - Background: Although strongly associated with tobacco and alcohol use, many oral cavity squamous cell carcinoma (OCSCC) cases occur in patients without exposure to either, known as “never-smoker, never-drinkers” (NSND). We aimed to compare clinical outcomes between NSND and tobacco/alcohol-exposed populations and to define demographic characteristics of NSND. Methods: We performed a retrospective, single-institution cohort study of 672 OCSCC patients. Cox models were used to estimate differences in overall survival (OS) and recurrence-free survival (RFS) between NSND and tobacco/alcohol-exposed patients while adjusting for confounders. Results: NSND represented 25.6% of our cohort and were older, more female, and more economically advantaged. Among NSND, oral tongue tumors dominated in younger patients, while alveolar ridge tumors dominated in elderly patients. Multivariate survival analysis revealed no differences in OS or RFS between NSND and tobacco/alcohol-exposed patients. Conclusion: When adjusted for independent biologic features, clinical outcomes in OCSCC are similar between NSND and tobacco/alcohol-exposed patients.

AB - Background: Although strongly associated with tobacco and alcohol use, many oral cavity squamous cell carcinoma (OCSCC) cases occur in patients without exposure to either, known as “never-smoker, never-drinkers” (NSND). We aimed to compare clinical outcomes between NSND and tobacco/alcohol-exposed populations and to define demographic characteristics of NSND. Methods: We performed a retrospective, single-institution cohort study of 672 OCSCC patients. Cox models were used to estimate differences in overall survival (OS) and recurrence-free survival (RFS) between NSND and tobacco/alcohol-exposed patients while adjusting for confounders. Results: NSND represented 25.6% of our cohort and were older, more female, and more economically advantaged. Among NSND, oral tongue tumors dominated in younger patients, while alveolar ridge tumors dominated in elderly patients. Multivariate survival analysis revealed no differences in OS or RFS between NSND and tobacco/alcohol-exposed patients. Conclusion: When adjusted for independent biologic features, clinical outcomes in OCSCC are similar between NSND and tobacco/alcohol-exposed patients.

KW - alcohol

KW - head and neck squamous cell carcinoma

KW - never-smoker never-drinker

KW - oral cavity squamous cell carcinoma

KW - survival

KW - tobacco

UR - http://www.scopus.com/inward/record.url?scp=85144212216&partnerID=8YFLogxK

U2 - 10.1002/hed.27266

DO - 10.1002/hed.27266

M3 - Article

C2 - 36524736

AN - SCOPUS:85144212216

SN - 1043-3074

VL - 45

SP - 567

EP - 577

JO - Head and Neck

JF - Head and Neck

IS - 3

ER -

No survival benefit in never-smoker never-drinker patients with oral cavity cancer

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this