No proof of linkage between schizophrenia-related disorders including schizophrenia and chromosome 2q21 region

Harald N. Aschauer; Gabriele Fischer; Keith E. Isenberg; Kurt Meszaros; Ulrike Willinger; Richard D. Todd; Henriette Beran; Rainer Strobl; Manuela Lang; Karoline Fuchs; Werner Sieghart; Theodore Reich; C. Robert Cloninger

doi:10.1007/BF02190727

No proof of linkage between schizophrenia-related disorders including schizophrenia and chromosome 2q21 region

Harald N. Aschauer, Gabriele Fischer, Keith E. Isenberg, Kurt Meszaros, Ulrike Willinger, Richard D. Todd, Henriette Beran, Rainer Strobl, Manuela Lang, Karoline Fuchs, Werner Sieghart, Theodore Reich, C. Robert Cloninger

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Abstract

We examined linkage between schizophrenia and schizophrenia-related disorders and five genetic markers on chromosome 2 in fourteen families ascertained through affected probands in St. Louis and Vienna. The chromosomal region 2q21 was considered a candidate locus for schizophrenia because of a report of a balanced translocation 2;18 (q21;q23) in a schizophrenia family. Linkage analyses were conducted for three disease models: a narrow model including schizophrenia only; an intermediate model including a spectrum of schizophrenia-related disorders; and a broad model including major affective disorders. Multipoint linkage analyses excluded linkage across the region (about 50c M) for the intermediate disease model. The same was generally true for the broad affection status model. None of the two-point and multipoint analyses showed definite linkage of schizophrenia to any marker. The most prominent positive association was between D2S44 and a broad affection status model, giving a two-point lod score of 1.71 at 0.20 recombination fraction.

Original language	English
Pages (from-to)	193-198
Number of pages	6
Journal	European Archives of Psychiatry and Clinical Neuroscience
Volume	243
Issue number	3-4
DOIs	https://doi.org/10.1007/BF02190727
State	Published - Nov 1993

Keywords

Chromosome 2
DNA markers
Linkage
Schizophrenia

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10.1007/BF02190727

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Aschauer, H. N., Fischer, G., Isenberg, K. E., Meszaros, K., Willinger, U., Todd, R. D., Beran, H., Strobl, R., Lang, M., Fuchs, K., Sieghart, W., Reich, T., & Cloninger, C. R. (1993). No proof of linkage between schizophrenia-related disorders including schizophrenia and chromosome 2q21 region. European Archives of Psychiatry and Clinical Neuroscience, 243(3-4), 193-198. https://doi.org/10.1007/BF02190727

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title = "No proof of linkage between schizophrenia-related disorders including schizophrenia and chromosome 2q21 region",

abstract = "We examined linkage between schizophrenia and schizophrenia-related disorders and five genetic markers on chromosome 2 in fourteen families ascertained through affected probands in St. Louis and Vienna. The chromosomal region 2q21 was considered a candidate locus for schizophrenia because of a report of a balanced translocation 2;18 (q21;q23) in a schizophrenia family. Linkage analyses were conducted for three disease models: a narrow model including schizophrenia only; an intermediate model including a spectrum of schizophrenia-related disorders; and a broad model including major affective disorders. Multipoint linkage analyses excluded linkage across the region (about 50c M) for the intermediate disease model. The same was generally true for the broad affection status model. None of the two-point and multipoint analyses showed definite linkage of schizophrenia to any marker. The most prominent positive association was between D2S44 and a broad affection status model, giving a two-point lod score of 1.71 at 0.20 recombination fraction.",

keywords = "Chromosome 2, DNA markers, Linkage, Schizophrenia",

author = "Aschauer, {Harald N.} and Gabriele Fischer and Isenberg, {Keith E.} and Kurt Meszaros and Ulrike Willinger and Todd, {Richard D.} and Henriette Beran and Rainer Strobl and Manuela Lang and Karoline Fuchs and Werner Sieghart and Theodore Reich and Cloninger, {C. Robert}",

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doi = "10.1007/BF02190727",

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Aschauer, HN, Fischer, G, Isenberg, KE, Meszaros, K, Willinger, U, Todd, RD, Beran, H, Strobl, R, Lang, M, Fuchs, K, Sieghart, W, Reich, T & Cloninger, CR 1993, 'No proof of linkage between schizophrenia-related disorders including schizophrenia and chromosome 2q21 region', European Archives of Psychiatry and Clinical Neuroscience, vol. 243, no. 3-4, pp. 193-198. https://doi.org/10.1007/BF02190727

TY - JOUR

T1 - No proof of linkage between schizophrenia-related disorders including schizophrenia and chromosome 2q21 region

AU - Aschauer, Harald N.

AU - Fischer, Gabriele

AU - Isenberg, Keith E.

AU - Meszaros, Kurt

AU - Willinger, Ulrike

AU - Todd, Richard D.

AU - Beran, Henriette

AU - Strobl, Rainer

AU - Lang, Manuela

AU - Fuchs, Karoline

AU - Sieghart, Werner

AU - Reich, Theodore

AU - Cloninger, C. Robert

PY - 1993/11

Y1 - 1993/11

N2 - We examined linkage between schizophrenia and schizophrenia-related disorders and five genetic markers on chromosome 2 in fourteen families ascertained through affected probands in St. Louis and Vienna. The chromosomal region 2q21 was considered a candidate locus for schizophrenia because of a report of a balanced translocation 2;18 (q21;q23) in a schizophrenia family. Linkage analyses were conducted for three disease models: a narrow model including schizophrenia only; an intermediate model including a spectrum of schizophrenia-related disorders; and a broad model including major affective disorders. Multipoint linkage analyses excluded linkage across the region (about 50c M) for the intermediate disease model. The same was generally true for the broad affection status model. None of the two-point and multipoint analyses showed definite linkage of schizophrenia to any marker. The most prominent positive association was between D2S44 and a broad affection status model, giving a two-point lod score of 1.71 at 0.20 recombination fraction.

AB - We examined linkage between schizophrenia and schizophrenia-related disorders and five genetic markers on chromosome 2 in fourteen families ascertained through affected probands in St. Louis and Vienna. The chromosomal region 2q21 was considered a candidate locus for schizophrenia because of a report of a balanced translocation 2;18 (q21;q23) in a schizophrenia family. Linkage analyses were conducted for three disease models: a narrow model including schizophrenia only; an intermediate model including a spectrum of schizophrenia-related disorders; and a broad model including major affective disorders. Multipoint linkage analyses excluded linkage across the region (about 50c M) for the intermediate disease model. The same was generally true for the broad affection status model. None of the two-point and multipoint analyses showed definite linkage of schizophrenia to any marker. The most prominent positive association was between D2S44 and a broad affection status model, giving a two-point lod score of 1.71 at 0.20 recombination fraction.

KW - Chromosome 2

KW - DNA markers

KW - Linkage

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JF - European Archives of Psychiatry and Clinical Neuroscience

IS - 3-4

ER -

No proof of linkage between schizophrenia-related disorders including schizophrenia and chromosome 2q21 region

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Keywords

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