No evidence of association between 118A>G OPRM1 polymorphism and heroin dependence in a large Bulgarian case-control sample

Momchil A. Nikolov; Olga Beltcheva; Antoaneta Galabova; Anna Ljubenova; Elena Jankova; Galin Gergov; Atanas A. Russev; Michael T. Lynskey; Elliot C. Nelson; Eleonora Nesheva; Dorita Krasteva; Philip Lazarov; Vanio I. Mitev; Ivo M. Kremensky; Radka P. Kaneva; Alexandre A. Todorov

doi:10.1016/j.drugalcdep.2010.12.026

No evidence of association between 118A>G OPRM1 polymorphism and heroin dependence in a large Bulgarian case-control sample

Momchil A. Nikolov, Olga Beltcheva, Antoaneta Galabova, Anna Ljubenova, Elena Jankova, Galin Gergov, Atanas A. Russev, Michael T. Lynskey, Elliot C. Nelson, Eleonora Nesheva, Dorita Krasteva, Philip Lazarov, Vanio I. Mitev, Ivo M. Kremensky, Radka P. Kaneva, Alexandre A. Todorov

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Abstract

The μ-opioid receptor is the primary site of action of most opioids. The 118A>G (rs1799971) polymorphism in exon 1 of the μ-opioid receptor gene (OPRM1) leads to an Asn40Asp amino acid change that affects a putative N-glycosylation site. It has been widely investigated for association with alcohol and drug dependence and pain sensitivity, with mixed results. The aim of the current study was to examine whether this polymorphism was associated with heroin dependence in a large Bulgarian cohort of 1842 active users and 1451 population controls. SNP genotyping was done using Real-Time PCR TaqMan technology. Association analyses were conducted, separately for Roma and non-Roma participants. Our results suggest that there is no direct effect of 118A>G genotype on the risk for heroin dependence among active heroin users.

Original language	English
Pages (from-to)	62-65
Number of pages	4
Journal	Drug and Alcohol Dependence
Volume	117
Issue number	1
DOIs	https://doi.org/10.1016/j.drugalcdep.2010.12.026
State	Published - Aug 1 2011

Keywords

118A>G
Association
Heroin dependence
OPRM1

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10.1016/j.drugalcdep.2010.12.026

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Nikolov, M. A., Beltcheva, O., Galabova, A., Ljubenova, A., Jankova, E., Gergov, G., Russev, A. A., Lynskey, M. T., Nelson, E. C., Nesheva, E., Krasteva, D., Lazarov, P., Mitev, V. I., Kremensky, I. M., Kaneva, R. P., & Todorov, A. A. (2011). No evidence of association between 118A>G OPRM1 polymorphism and heroin dependence in a large Bulgarian case-control sample. Drug and Alcohol Dependence, 117(1), 62-65. https://doi.org/10.1016/j.drugalcdep.2010.12.026

@article{1dc3bd2a43664691a4a9d8e464c4740d,

title = "No evidence of association between 118A>G OPRM1 polymorphism and heroin dependence in a large Bulgarian case-control sample",

abstract = "The μ-opioid receptor is the primary site of action of most opioids. The 118A>G (rs1799971) polymorphism in exon 1 of the μ-opioid receptor gene (OPRM1) leads to an Asn40Asp amino acid change that affects a putative N-glycosylation site. It has been widely investigated for association with alcohol and drug dependence and pain sensitivity, with mixed results. The aim of the current study was to examine whether this polymorphism was associated with heroin dependence in a large Bulgarian cohort of 1842 active users and 1451 population controls. SNP genotyping was done using Real-Time PCR TaqMan technology. Association analyses were conducted, separately for Roma and non-Roma participants. Our results suggest that there is no direct effect of 118A>G genotype on the risk for heroin dependence among active heroin users.",

keywords = "118A>G, Association, Heroin dependence, OPRM1",

author = "Nikolov, {Momchil A.} and Olga Beltcheva and Antoaneta Galabova and Anna Ljubenova and Elena Jankova and Galin Gergov and Russev, {Atanas A.} and Lynskey, {Michael T.} and Nelson, {Elliot C.} and Eleonora Nesheva and Dorita Krasteva and Philip Lazarov and Mitev, {Vanio I.} and Kremensky, {Ivo M.} and Kaneva, {Radka P.} and Todorov, {Alexandre A.}",

note = "Funding Information: Supported by grant R01 DA018823 from the National Institute on Drug Abuse to Alexandre Todorov and T32 training grant GM081739 from National Institute of General Medical Sciences to Randall Larsen. ",

year = "2011",

month = aug,

day = "1",

doi = "10.1016/j.drugalcdep.2010.12.026",

language = "English",

volume = "117",

pages = "62--65",

journal = "Drug and Alcohol Dependence",

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Nikolov, MA, Beltcheva, O, Galabova, A, Ljubenova, A, Jankova, E, Gergov, G, Russev, AA, Lynskey, MT, Nelson, EC, Nesheva, E, Krasteva, D, Lazarov, P, Mitev, VI, Kremensky, IM, Kaneva, RP & Todorov, AA 2011, 'No evidence of association between 118A>G OPRM1 polymorphism and heroin dependence in a large Bulgarian case-control sample', Drug and Alcohol Dependence, vol. 117, no. 1, pp. 62-65. https://doi.org/10.1016/j.drugalcdep.2010.12.026

TY - JOUR

T1 - No evidence of association between 118A>G OPRM1 polymorphism and heroin dependence in a large Bulgarian case-control sample

AU - Nikolov, Momchil A.

AU - Beltcheva, Olga

AU - Galabova, Antoaneta

AU - Ljubenova, Anna

AU - Jankova, Elena

AU - Gergov, Galin

AU - Russev, Atanas A.

AU - Lynskey, Michael T.

AU - Nelson, Elliot C.

AU - Nesheva, Eleonora

AU - Krasteva, Dorita

AU - Lazarov, Philip

AU - Mitev, Vanio I.

AU - Kremensky, Ivo M.

AU - Kaneva, Radka P.

AU - Todorov, Alexandre A.

N1 - Funding Information: Supported by grant R01 DA018823 from the National Institute on Drug Abuse to Alexandre Todorov and T32 training grant GM081739 from National Institute of General Medical Sciences to Randall Larsen.

PY - 2011/8/1

Y1 - 2011/8/1

N2 - The μ-opioid receptor is the primary site of action of most opioids. The 118A>G (rs1799971) polymorphism in exon 1 of the μ-opioid receptor gene (OPRM1) leads to an Asn40Asp amino acid change that affects a putative N-glycosylation site. It has been widely investigated for association with alcohol and drug dependence and pain sensitivity, with mixed results. The aim of the current study was to examine whether this polymorphism was associated with heroin dependence in a large Bulgarian cohort of 1842 active users and 1451 population controls. SNP genotyping was done using Real-Time PCR TaqMan technology. Association analyses were conducted, separately for Roma and non-Roma participants. Our results suggest that there is no direct effect of 118A>G genotype on the risk for heroin dependence among active heroin users.

AB - The μ-opioid receptor is the primary site of action of most opioids. The 118A>G (rs1799971) polymorphism in exon 1 of the μ-opioid receptor gene (OPRM1) leads to an Asn40Asp amino acid change that affects a putative N-glycosylation site. It has been widely investigated for association with alcohol and drug dependence and pain sensitivity, with mixed results. The aim of the current study was to examine whether this polymorphism was associated with heroin dependence in a large Bulgarian cohort of 1842 active users and 1451 population controls. SNP genotyping was done using Real-Time PCR TaqMan technology. Association analyses were conducted, separately for Roma and non-Roma participants. Our results suggest that there is no direct effect of 118A>G genotype on the risk for heroin dependence among active heroin users.

KW - 118A>G

KW - Association

KW - Heroin dependence

KW - OPRM1

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C2 - 21277709

AN - SCOPUS:79959671535

SN - 0376-8716

VL - 117

SP - 62

EP - 65

JO - Drug and Alcohol Dependence

JF - Drug and Alcohol Dependence

IS - 1

ER -

No evidence of association between 118A>G OPRM1 polymorphism and heroin dependence in a large Bulgarian case-control sample

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Keywords

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