No evidence of association between 118A>G OPRM1 polymorphism and heroin dependence in a large Bulgarian case-control sample

Momchil A. Nikolov, Olga Beltcheva, Antoaneta Galabova, Anna Ljubenova, Elena Jankova, Galin Gergov, Atanas A. Russev, Michael T. Lynskey, Elliot C. Nelson, Eleonora Nesheva, Dorita Krasteva, Philip Lazarov, Vanio I. Mitev, Ivo M. Kremensky, Radka P. Kaneva, Alexandre A. Todorov

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Abstract

The μ-opioid receptor is the primary site of action of most opioids. The 118A>G (rs1799971) polymorphism in exon 1 of the μ-opioid receptor gene (OPRM1) leads to an Asn40Asp amino acid change that affects a putative N-glycosylation site. It has been widely investigated for association with alcohol and drug dependence and pain sensitivity, with mixed results. The aim of the current study was to examine whether this polymorphism was associated with heroin dependence in a large Bulgarian cohort of 1842 active users and 1451 population controls. SNP genotyping was done using Real-Time PCR TaqMan technology. Association analyses were conducted, separately for Roma and non-Roma participants. Our results suggest that there is no direct effect of 118A>G genotype on the risk for heroin dependence among active heroin users.

Original languageEnglish
Pages (from-to)62-65
Number of pages4
JournalDrug and Alcohol Dependence
Volume117
Issue number1
DOIs
StatePublished - Aug 1 2011

Keywords

  • 118A>G
  • Association
  • Heroin dependence
  • OPRM1

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    Nikolov, M. A., Beltcheva, O., Galabova, A., Ljubenova, A., Jankova, E., Gergov, G., Russev, A. A., Lynskey, M. T., Nelson, E. C., Nesheva, E., Krasteva, D., Lazarov, P., Mitev, V. I., Kremensky, I. M., Kaneva, R. P., & Todorov, A. A. (2011). No evidence of association between 118A>G OPRM1 polymorphism and heroin dependence in a large Bulgarian case-control sample. Drug and Alcohol Dependence, 117(1), 62-65. https://doi.org/10.1016/j.drugalcdep.2010.12.026