No evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found

Janel Johnson, Jovanka Ostojic, Lars Lannfelt, Anna Glaser, Hans Basun, Ekaterina Rogaeva, Toshitaka Kawarai, Amalia Bruni, Peter H. St. George Hyslop, Alison Goate, Pau Pastor, Sumi Chakraverty, Joanne Norton, John C. Morris, John Hardy, Andrew Singleton

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Given the remarkable similarities between the genetics of tau diseases and the genetics of α-synuclein diseases, and given the fact that we have recently found a triplication of the α-synuclein locus in a family in which we had shown linkage to the α-synuclein locus, we determined to test whether some of the several families with autosomal dominant frontal temporal dementia which show genetic linkage to the tau locus but in which tau mutations have not been found could be caused by similar structural mutations. We did not find any such mutations.

Original languageEnglish
Pages (from-to)99-101
Number of pages3
JournalNeuroscience Letters
Volume363
Issue number2
DOIs
StatePublished - Jun 10 2004

Keywords

  • FTDP-17
  • Genetics
  • MAPT
  • Tau
  • α-Synuclein

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