No evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found

Janel Johnson; Jovanka Ostojic; Lars Lannfelt; Anna Glaser; Hans Basun; Ekaterina Rogaeva; Toshitaka Kawarai; Amalia Bruni; Peter H. St. George Hyslop; Alison Goate; Pau Pastor; Sumi Chakraverty; Joanne Norton; John C. Morris; John Hardy; Andrew Singleton

doi:10.1016/j.neulet.2004.03.070

No evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found

Janel Johnson, Jovanka Ostojic, Lars Lannfelt, Anna Glaser, Hans Basun, Ekaterina Rogaeva, Toshitaka Kawarai, Amalia Bruni, Peter H. St. George Hyslop, Alison Goate, Pau Pastor, Sumi Chakraverty, Joanne Norton, John C. Morris, John Hardy, Andrew Singleton

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7 Scopus citations

Abstract

Given the remarkable similarities between the genetics of tau diseases and the genetics of α-synuclein diseases, and given the fact that we have recently found a triplication of the α-synuclein locus in a family in which we had shown linkage to the α-synuclein locus, we determined to test whether some of the several families with autosomal dominant frontal temporal dementia which show genetic linkage to the tau locus but in which tau mutations have not been found could be caused by similar structural mutations. We did not find any such mutations.

Original language	English
Pages (from-to)	99-101
Number of pages	3
Journal	Neuroscience Letters
Volume	363
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2004.03.070
State	Published - Jun 10 2004

Keywords

FTDP-17
Genetics
MAPT
Tau
α-Synuclein

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Johnson, J., Ostojic, J., Lannfelt, L., Glaser, A., Basun, H., Rogaeva, E., Kawarai, T., Bruni, A., St. George Hyslop, P. H., Goate, A., Pastor, P., Chakraverty, S., Norton, J., Morris, J. C., Hardy, J., & Singleton, A. (2004). No evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found. Neuroscience Letters, 363(2), 99-101. https://doi.org/10.1016/j.neulet.2004.03.070

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title = "No evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found",

abstract = "Given the remarkable similarities between the genetics of tau diseases and the genetics of α-synuclein diseases, and given the fact that we have recently found a triplication of the α-synuclein locus in a family in which we had shown linkage to the α-synuclein locus, we determined to test whether some of the several families with autosomal dominant frontal temporal dementia which show genetic linkage to the tau locus but in which tau mutations have not been found could be caused by similar structural mutations. We did not find any such mutations.",

keywords = "FTDP-17, Genetics, MAPT, Tau, α-Synuclein",

author = "Janel Johnson and Jovanka Ostojic and Lars Lannfelt and Anna Glaser and Hans Basun and Ekaterina Rogaeva and Toshitaka Kawarai and Amalia Bruni and {St. George Hyslop}, {Peter H.} and Alison Goate and Pau Pastor and Sumi Chakraverty and Joanne Norton and Morris, {John C.} and John Hardy and Andrew Singleton",

year = "2004",

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doi = "10.1016/j.neulet.2004.03.070",

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Johnson, J, Ostojic, J, Lannfelt, L, Glaser, A, Basun, H, Rogaeva, E, Kawarai, T, Bruni, A, St. George Hyslop, PH, Goate, A, Pastor, P, Chakraverty, S, Norton, J, Morris, JC, Hardy, J & Singleton, A 2004, 'No evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found', Neuroscience Letters, vol. 363, no. 2, pp. 99-101. https://doi.org/10.1016/j.neulet.2004.03.070

TY - JOUR

T1 - No evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found

AU - Johnson, Janel

AU - Ostojic, Jovanka

AU - Lannfelt, Lars

AU - Glaser, Anna

AU - Basun, Hans

AU - Rogaeva, Ekaterina

AU - Kawarai, Toshitaka

AU - Bruni, Amalia

AU - St. George Hyslop, Peter H.

AU - Goate, Alison

AU - Pastor, Pau

AU - Chakraverty, Sumi

AU - Norton, Joanne

AU - Morris, John C.

AU - Hardy, John

AU - Singleton, Andrew

PY - 2004/6/10

Y1 - 2004/6/10

N2 - Given the remarkable similarities between the genetics of tau diseases and the genetics of α-synuclein diseases, and given the fact that we have recently found a triplication of the α-synuclein locus in a family in which we had shown linkage to the α-synuclein locus, we determined to test whether some of the several families with autosomal dominant frontal temporal dementia which show genetic linkage to the tau locus but in which tau mutations have not been found could be caused by similar structural mutations. We did not find any such mutations.

AB - Given the remarkable similarities between the genetics of tau diseases and the genetics of α-synuclein diseases, and given the fact that we have recently found a triplication of the α-synuclein locus in a family in which we had shown linkage to the α-synuclein locus, we determined to test whether some of the several families with autosomal dominant frontal temporal dementia which show genetic linkage to the tau locus but in which tau mutations have not been found could be caused by similar structural mutations. We did not find any such mutations.

KW - FTDP-17

KW - Genetics

KW - MAPT

KW - Tau

KW - α-Synuclein

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AN - SCOPUS:2542502499

SN - 0304-3940

VL - 363

SP - 99

EP - 101

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

No evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found

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Keywords

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