No-carrier-added radiosynthesis of [¹²³I]HIPDM: N,N,N′-trimethyl-N′-(2-hydroxy-3-methyl-5-[¹²³I]i odobenzyl)-1,3-propanediamine

The multi-millicurie production of the SPECT radiopharmaceutical N,N,N′-trimethyl-N′-(2-hydroxy-3-methyl-5-[¹²³I]i odobenzyl)-1,3-propanediamine ([¹²³I]HIPDM) in high specific activity is described. Using no-carrier-added electrophilic iododeprotonation reactions and HPLC purification, [¹²³I]HIPDM can be isolated in 70-76% radiochemical yield and specific activity >2000 Ci/mmol within an overall preparation time of 75 min. This methodology is readily adapted to the clinical setting, and eliminates the need for co-injection of macroscopic HIPDM in SPECT imaging procedures.