TY - JOUR
T1 - No-carrier-added radiosynthesis of [123I]HIPDM
T2 - N,N,N′-trimethyl-N′-(2-hydroxy-3-methyl-5-[123I]i odobenzyl)-1,3-propanediamine
AU - Moerlein, S. M.
AU - Lannoye, G. S.
AU - Welch, M. J.
PY - 1990
Y1 - 1990
N2 - The multi-millicurie production of the SPECT radiopharmaceutical N,N,N′-trimethyl-N′-(2-hydroxy-3-methyl-5-[123I]i odobenzyl)-1,3-propanediamine ([123I]HIPDM) in high specific activity is described. Using no-carrier-added electrophilic iododeprotonation reactions and HPLC purification, [123I]HIPDM can be isolated in 70-76% radiochemical yield and specific activity >2000 Ci/mmol within an overall preparation time of 75 min. This methodology is readily adapted to the clinical setting, and eliminates the need for co-injection of macroscopic HIPDM in SPECT imaging procedures.
AB - The multi-millicurie production of the SPECT radiopharmaceutical N,N,N′-trimethyl-N′-(2-hydroxy-3-methyl-5-[123I]i odobenzyl)-1,3-propanediamine ([123I]HIPDM) in high specific activity is described. Using no-carrier-added electrophilic iododeprotonation reactions and HPLC purification, [123I]HIPDM can be isolated in 70-76% radiochemical yield and specific activity >2000 Ci/mmol within an overall preparation time of 75 min. This methodology is readily adapted to the clinical setting, and eliminates the need for co-injection of macroscopic HIPDM in SPECT imaging procedures.
UR - http://www.scopus.com/inward/record.url?scp=0025319192&partnerID=8YFLogxK
U2 - 10.1016/0883-2889(90)90188-M
DO - 10.1016/0883-2889(90)90188-M
M3 - Article
C2 - 2158950
AN - SCOPUS:0025319192
SN - 0883-2889
VL - 41
SP - 253
EP - 257
JO - International Journal of Radiation Applications and Instrumentation. Part
JF - International Journal of Radiation Applications and Instrumentation. Part
IS - 3
ER -