No-Carrier-Added Radiohalogenation Methods with Heavy Halogens

H. H. Coenen; S. M. Moerlein; G. StCklin

doi:10.1524/ract.1983.34.12.47

No-Carrier-Added Radiohalogenation Methods with Heavy Halogens

H. H. Coenen, S. M. Moerlein, G. StCklin

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125 Scopus citations

Abstract

Radiolabeling methods with the heavy halogens bromine, iodine and astatine are reviewed. The methods are evaluated on the basis of their underlying chemical principles and their usefulness for the no-carrier-added labeling of biologically-useful Compounds. Special emphasis is placed on the stability, specific activity, and quality control of radiohalogenation products using the short-lived, neutron-deficient nuclides 75,77Br, 123I,and 211At in view of their importance as radiopharmaceuticals.

Original language	English
Pages (from-to)	47-68
Number of pages	22
Journal	Radiochimica Acta
Volume	34
Issue number	1-2
DOIs	https://doi.org/10.1524/ract.1983.34.12.47
State	Published - Oct 1983

Keywords

123,125,131,I,211 At
75,77 Br
Halogenated radiopharmaceu ticals
Radiohalogenation
n.c.a laheling

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10.1524/ract.1983.34.12.47

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abstract = "Radiolabeling methods with the heavy halogens bromine, iodine and astatine are reviewed. The methods are evaluated on the basis of their underlying chemical principles and their usefulness for the no-carrier-added labeling of biologically-useful Compounds. Special emphasis is placed on the stability, specific activity, and quality control of radiohalogenation products using the short-lived, neutron-deficient nuclides 75,77Br, 123I,and 211At in view of their importance as radiopharmaceuticals.",

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author = "Coenen, {H. H.} and Moerlein, {S. M.} and G. StCklin",

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N2 - Radiolabeling methods with the heavy halogens bromine, iodine and astatine are reviewed. The methods are evaluated on the basis of their underlying chemical principles and their usefulness for the no-carrier-added labeling of biologically-useful Compounds. Special emphasis is placed on the stability, specific activity, and quality control of radiohalogenation products using the short-lived, neutron-deficient nuclides 75,77Br, 123I,and 211At in view of their importance as radiopharmaceuticals.

AB - Radiolabeling methods with the heavy halogens bromine, iodine and astatine are reviewed. The methods are evaluated on the basis of their underlying chemical principles and their usefulness for the no-carrier-added labeling of biologically-useful Compounds. Special emphasis is placed on the stability, specific activity, and quality control of radiohalogenation products using the short-lived, neutron-deficient nuclides 75,77Br, 123I,and 211At in view of their importance as radiopharmaceuticals.

KW - 123,125,131,I,211 At

KW - 75,77 Br

KW - Halogenated radiopharmaceu ticals

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No-Carrier-Added Radiohalogenation Methods with Heavy Halogens

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Keywords

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