Radiolabeling methods with the heavy halogens bromine, iodine and astatine are reviewed. The methods are evaluated on the basis of their underlying chemical principles and their usefulness for the no-carrier-added labeling of biologically-useful Compounds. Special emphasis is placed on the stability, specific activity, and quality control of radiohalogenation products using the short-lived, neutron-deficient nuclides 75,77Br, 123I,and 211At in view of their importance as radiopharmaceuticals.
- 123,125,131,I,211 At
- 75,77 Br
- Halogenated radiopharmaceu ticals
- n.c.a laheling