TY - JOUR
T1 - No-carrier-added radiobromination via cuprous chloride-assisted nucleophilic aromatic bromodeiodination
AU - Moerlein, S. M.
AU - Hwang, D. R.
AU - Welch, M. J.
N1 - Funding Information:
Acknowledgemenl-This work was supported in part by DOE Grant DE-FG02-84ER60218.
PY - 1988
Y1 - 1988
N2 - Cuprous chloride-assisted aromatic bromodeiodination was investigated as a regioselective no-carrier-added labelling technique. Using 77Br-1, CuCl and simple iodinated aromatic substrates in DMSO, radiochemical yields ranged from 60 to 90% after 30 min at 135°C. The methodology described here holds potential for the convenient labelling of radiopharmaceuticals with 75Br, 76Br or 77Br.
AB - Cuprous chloride-assisted aromatic bromodeiodination was investigated as a regioselective no-carrier-added labelling technique. Using 77Br-1, CuCl and simple iodinated aromatic substrates in DMSO, radiochemical yields ranged from 60 to 90% after 30 min at 135°C. The methodology described here holds potential for the convenient labelling of radiopharmaceuticals with 75Br, 76Br or 77Br.
UR - http://www.scopus.com/inward/record.url?scp=0023898989&partnerID=8YFLogxK
U2 - 10.1016/0883-2889(88)90064-0
DO - 10.1016/0883-2889(88)90064-0
M3 - Article
C2 - 2840411
AN - SCOPUS:0023898989
SN - 0883-2889
VL - 39
SP - 369
EP - 372
JO - International Journal of Radiation Applications and Instrumentation. Part
JF - International Journal of Radiation Applications and Instrumentation. Part
IS - 5
ER -