No-carrier-added radiobromination via cuprous chloride-assisted nucleophilic aromatic bromodeiodination

S. M. Moerlein, D. R. Hwang, M. J. Welch

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Cuprous chloride-assisted aromatic bromodeiodination was investigated as a regioselective no-carrier-added labelling technique. Using 77Br-1, CuCl and simple iodinated aromatic substrates in DMSO, radiochemical yields ranged from 60 to 90% after 30 min at 135°C. The methodology described here holds potential for the convenient labelling of radiopharmaceuticals with 75Br, 76Br or 77Br.

Original languageEnglish
Pages (from-to)369-372
Number of pages4
JournalInternational Journal of Radiation Applications and Instrumentation. Part
Volume39
Issue number5
DOIs
StatePublished - 1988

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