No association of candidate genes with cannabis use in a large sample of Australian twin families

Karin J.H. Verweij; Brendan P. Zietsch; Jimmy Z. Liu; Sarah E. Medland; Michael T. Lynskey; Pamela A.F. Madden; Arpana Agrawal; Grant W. Montgomery; Andrew C. Heath; Nicholas G. Martin

doi:10.1111/j.1369-1600.2011.00320.x

No association of candidate genes with cannabis use in a large sample of Australian twin families

Karin J.H. Verweij, Brendan P. Zietsch, Jimmy Z. Liu, Sarah E. Medland, Michael T. Lynskey, Pamela A.F. Madden, Arpana Agrawal, Grant W. Montgomery, Andrew C. Heath, Nicholas G. Martin

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

While there is solid evidence that cannabis use is heritable, attempts to identify genetic influences at the molecular level have yielded mixed results. Here, a large twin family sample (n = 7452) was used to test for association between 10 previously reported candidate genes and lifetime frequency of cannabis use using a gene-based association test. None of the candidate genes reached even nominal significance (P < 0.05). The lack of replication may point to our limited understanding of the neurobiology of cannabis involvement and also to potential publication bias and false-positive findings in previous studies.

Original language	English
Pages (from-to)	687-690
Number of pages	4
Journal	Addiction Biology
Volume	17
Issue number	3
DOIs	https://doi.org/10.1111/j.1369-1600.2011.00320.x
State	Published - May 2012

Keywords

Association
cannabis
drug
genes
genetics
replication

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10.1111/j.1369-1600.2011.00320.x

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title = "No association of candidate genes with cannabis use in a large sample of Australian twin families",

abstract = "While there is solid evidence that cannabis use is heritable, attempts to identify genetic influences at the molecular level have yielded mixed results. Here, a large twin family sample (n = 7452) was used to test for association between 10 previously reported candidate genes and lifetime frequency of cannabis use using a gene-based association test. None of the candidate genes reached even nominal significance (P < 0.05). The lack of replication may point to our limited understanding of the neurobiology of cannabis involvement and also to potential publication bias and false-positive findings in previous studies.",

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AU - Verweij, Karin J.H.

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AU - Lynskey, Michael T.

AU - Madden, Pamela A.F.

AU - Agrawal, Arpana

AU - Montgomery, Grant W.

AU - Heath, Andrew C.

AU - Martin, Nicholas G.

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N2 - While there is solid evidence that cannabis use is heritable, attempts to identify genetic influences at the molecular level have yielded mixed results. Here, a large twin family sample (n = 7452) was used to test for association between 10 previously reported candidate genes and lifetime frequency of cannabis use using a gene-based association test. None of the candidate genes reached even nominal significance (P < 0.05). The lack of replication may point to our limited understanding of the neurobiology of cannabis involvement and also to potential publication bias and false-positive findings in previous studies.

AB - While there is solid evidence that cannabis use is heritable, attempts to identify genetic influences at the molecular level have yielded mixed results. Here, a large twin family sample (n = 7452) was used to test for association between 10 previously reported candidate genes and lifetime frequency of cannabis use using a gene-based association test. None of the candidate genes reached even nominal significance (P < 0.05). The lack of replication may point to our limited understanding of the neurobiology of cannabis involvement and also to potential publication bias and false-positive findings in previous studies.

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KW - drug

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No association of candidate genes with cannabis use in a large sample of Australian twin families

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Keywords

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