@article{5dc10c2a79e046cdbdba78ce63772fe6,
title = "No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease",
abstract = "Recent reports have suggested that variability in the α2-macroglobulin gene is a genetic risk factor for Alzheimer's disease. Here we have both tested a common polyrdorphism in the gene (I1000V) for association with the disease in a four-site case control study design, and tested the locus for linkage in a large series of sibpairs afflicted with late onset disease. Our results fail to show an association between this polymorphism and disease.",
keywords = "Alzheimer's disease, Apolipoprotein E, Genetics, α2-macroglobulin",
author = "Fabienne Wavrant-Devri{\`e}ze and Varuni Rudrasingham and Lambert, \{Jean Charles\} and Sumi Chakraverty and Patrick Kehoe and Richard Crook and Philippe Amouyel and William Wu and Peter Holmans and Francis Rice and Jordi P{\'e}rez-Tur and Bernard Frigard and Morris, \{John C.\} and Stephanie Carty and Dominique Cottel and Nigel Tunstall and Simon Lovestone and Petersen, \{Ronald C.\} and Chartier-Harlin, \{Marie Christine\} and Alison Goate and Owen, \{Michael J.\} and Julie Williams and John Hardy",
note = "Funding Information: This work was supported by the Medical Research Council (UK), the Institut National pour la Sant{\'e} Et la Recherche M{\'e}dicale (INSERM), the Institut Pasteur de Lille, the Conseil R{\'e}gional du Nord-Pas de Calais axe r{\'e}gional de recherche sur les maladies neurod{\'e}g{\'e}n{\'e}ratives et le vieillissement c{\'e}r{\'e}bral, and the Fondation pour la Recherche M{\'e}dicale, The Mayo Foundation, National Institute of Health, the Alzheimer's Disease Association and the Nettie and Rebecca Brown Foundation. We also wish to thank the clinicians and staff of the Mayo Institute and Washington University, School of Medicine.",
year = "1999",
month = mar,
day = "5",
doi = "10.1016/S0304-3940(99)00035-X",
language = "English",
volume = "262",
pages = "137--139",
journal = "Neuroscience Letters",
issn = "0304-3940",
number = "2",
}