No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease

Fabienne Wavrant-Devrièze; Varuni Rudrasingham; Jean Charles Lambert; Sumi Chakraverty; Patrick Kehoe; Richard Crook; Philippe Amouyel; William Wu; Peter Holmans; Francis Rice; Jordi Pérez-Tur; Bernard Frigard; John C. Morris; Stephanie Carty; Dominique Cottel; Nigel Tunstall; Simon Lovestone; Ronald C. Petersen; Marie Christine Chartier-Harlin; Alison Goate; Michael J. Owen; Julie Williams; John Hardy

doi:10.1016/S0304-3940(99)00035-X

No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease

Fabienne Wavrant-Devrièze, Varuni Rudrasingham, Jean Charles Lambert, Sumi Chakraverty, Patrick Kehoe, Richard Crook, Philippe Amouyel, William Wu, Peter Holmans, Francis Rice, Jordi Pérez-Tur, Bernard Frigard, John C. Morris, Stephanie Carty, Dominique Cottel, Nigel Tunstall, Simon Lovestone, Ronald C. Petersen, Marie Christine Chartier-Harlin, Alison GoateMichael J. Owen, Julie Williams, John Hardy

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Abstract

Recent reports have suggested that variability in the α2-macroglobulin gene is a genetic risk factor for Alzheimer's disease. Here we have both tested a common polyrdorphism in the gene (I1000V) for association with the disease in a four-site case control study design, and tested the locus for linkage in a large series of sibpairs afflicted with late onset disease. Our results fail to show an association between this polymorphism and disease.

Original language	English
Pages (from-to)	137-139
Number of pages	3
Journal	Neuroscience Letters
Volume	262
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3940(99)00035-X
State	Published - Mar 5 1999

Keywords

Alzheimer's disease
Apolipoprotein E
Genetics
α2-macroglobulin

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10.1016/S0304-3940(99)00035-X

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Wavrant-Devrièze, F., Rudrasingham, V., Lambert, J. C., Chakraverty, S., Kehoe, P., Crook, R., Amouyel, P., Wu, W., Holmans, P., Rice, F., Pérez-Tur, J., Frigard, B., Morris, J. C., Carty, S., Cottel, D., Tunstall, N., Lovestone, S., Petersen, R. C., Chartier-Harlin, M. C., ... Hardy, J. (1999). No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease. Neuroscience Letters, 262(2), 137-139. https://doi.org/10.1016/S0304-3940(99)00035-X

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title = "No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease",

abstract = "Recent reports have suggested that variability in the α2-macroglobulin gene is a genetic risk factor for Alzheimer's disease. Here we have both tested a common polyrdorphism in the gene (I1000V) for association with the disease in a four-site case control study design, and tested the locus for linkage in a large series of sibpairs afflicted with late onset disease. Our results fail to show an association between this polymorphism and disease.",

keywords = "Alzheimer's disease, Apolipoprotein E, Genetics, α2-macroglobulin",

author = "Fabienne Wavrant-Devri{\`e}ze and Varuni Rudrasingham and Lambert, {Jean Charles} and Sumi Chakraverty and Patrick Kehoe and Richard Crook and Philippe Amouyel and William Wu and Peter Holmans and Francis Rice and Jordi P{\'e}rez-Tur and Bernard Frigard and Morris, {John C.} and Stephanie Carty and Dominique Cottel and Nigel Tunstall and Simon Lovestone and Petersen, {Ronald C.} and Chartier-Harlin, {Marie Christine} and Alison Goate and Owen, {Michael J.} and Julie Williams and John Hardy",

note = "Funding Information: This work was supported by the Medical Research Council (UK), the Institut National pour la Sant{\'e} Et la Recherche M{\'e}dicale (INSERM), the Institut Pasteur de Lille, the Conseil R{\'e}gional du Nord-Pas de Calais axe r{\'e}gional de recherche sur les maladies neurod{\'e}g{\'e}n{\'e}ratives et le vieillissement c{\'e}r{\'e}bral, and the Fondation pour la Recherche M{\'e}dicale, The Mayo Foundation, National Institute of Health, the Alzheimer's Disease Association and the Nettie and Rebecca Brown Foundation. We also wish to thank the clinicians and staff of the Mayo Institute and Washington University, School of Medicine.",

year = "1999",

month = mar,

day = "5",

doi = "10.1016/S0304-3940(99)00035-X",

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Wavrant-Devrièze, F, Rudrasingham, V, Lambert, JC, Chakraverty, S, Kehoe, P, Crook, R, Amouyel, P, Wu, W, Holmans, P, Rice, F, Pérez-Tur, J, Frigard, B, Morris, JC, Carty, S, Cottel, D, Tunstall, N, Lovestone, S, Petersen, RC, Chartier-Harlin, MC, Goate, A, Owen, MJ, Williams, J & Hardy, J 1999, 'No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease', Neuroscience Letters, vol. 262, no. 2, pp. 137-139. https://doi.org/10.1016/S0304-3940(99)00035-X

TY - JOUR

T1 - No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease

AU - Wavrant-Devrièze, Fabienne

AU - Rudrasingham, Varuni

AU - Lambert, Jean Charles

AU - Chakraverty, Sumi

AU - Kehoe, Patrick

AU - Crook, Richard

AU - Amouyel, Philippe

AU - Wu, William

AU - Holmans, Peter

AU - Rice, Francis

AU - Pérez-Tur, Jordi

AU - Frigard, Bernard

AU - Morris, John C.

AU - Carty, Stephanie

AU - Cottel, Dominique

AU - Tunstall, Nigel

AU - Lovestone, Simon

AU - Petersen, Ronald C.

AU - Chartier-Harlin, Marie Christine

AU - Goate, Alison

AU - Owen, Michael J.

AU - Williams, Julie

AU - Hardy, John

N1 - Funding Information: This work was supported by the Medical Research Council (UK), the Institut National pour la Santé Et la Recherche Médicale (INSERM), the Institut Pasteur de Lille, the Conseil Régional du Nord-Pas de Calais axe régional de recherche sur les maladies neurodégénératives et le vieillissement cérébral, and the Fondation pour la Recherche Médicale, The Mayo Foundation, National Institute of Health, the Alzheimer's Disease Association and the Nettie and Rebecca Brown Foundation. We also wish to thank the clinicians and staff of the Mayo Institute and Washington University, School of Medicine.

PY - 1999/3/5

Y1 - 1999/3/5

N2 - Recent reports have suggested that variability in the α2-macroglobulin gene is a genetic risk factor for Alzheimer's disease. Here we have both tested a common polyrdorphism in the gene (I1000V) for association with the disease in a four-site case control study design, and tested the locus for linkage in a large series of sibpairs afflicted with late onset disease. Our results fail to show an association between this polymorphism and disease.

AB - Recent reports have suggested that variability in the α2-macroglobulin gene is a genetic risk factor for Alzheimer's disease. Here we have both tested a common polyrdorphism in the gene (I1000V) for association with the disease in a four-site case control study design, and tested the locus for linkage in a large series of sibpairs afflicted with late onset disease. Our results fail to show an association between this polymorphism and disease.

KW - Alzheimer's disease

KW - Apolipoprotein E

KW - Genetics

KW - α2-macroglobulin

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U2 - 10.1016/S0304-3940(99)00035-X

DO - 10.1016/S0304-3940(99)00035-X

M3 - Article

C2 - 10203250

AN - SCOPUS:0033525766

SN - 0304-3940

VL - 262

SP - 137

EP - 139

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease

Abstract

Keywords

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