TY - JOUR
T1 - No association between the alpha-2 macroglobulin I1000V polymorphism and Alzheimer's disease
AU - Wavrant-Devrièze, Fabienne
AU - Rudrasingham, Varuni
AU - Lambert, Jean Charles
AU - Chakraverty, Sumi
AU - Kehoe, Patrick
AU - Crook, Richard
AU - Amouyel, Philippe
AU - Wu, William
AU - Holmans, Peter
AU - Rice, Francis
AU - Pérez-Tur, Jordi
AU - Frigard, Bernard
AU - Morris, John C.
AU - Carty, Stephanie
AU - Cottel, Dominique
AU - Tunstall, Nigel
AU - Lovestone, Simon
AU - Petersen, Ronald C.
AU - Chartier-Harlin, Marie Christine
AU - Goate, Alison
AU - Owen, Michael J.
AU - Williams, Julie
AU - Hardy, John
N1 - Funding Information:
This work was supported by the Medical Research Council (UK), the Institut National pour la Santé Et la Recherche Médicale (INSERM), the Institut Pasteur de Lille, the Conseil Régional du Nord-Pas de Calais axe régional de recherche sur les maladies neurodégénératives et le vieillissement cérébral, and the Fondation pour la Recherche Médicale, The Mayo Foundation, National Institute of Health, the Alzheimer's Disease Association and the Nettie and Rebecca Brown Foundation. We also wish to thank the clinicians and staff of the Mayo Institute and Washington University, School of Medicine.
PY - 1999/3/5
Y1 - 1999/3/5
N2 - Recent reports have suggested that variability in the α2-macroglobulin gene is a genetic risk factor for Alzheimer's disease. Here we have both tested a common polyrdorphism in the gene (I1000V) for association with the disease in a four-site case control study design, and tested the locus for linkage in a large series of sibpairs afflicted with late onset disease. Our results fail to show an association between this polymorphism and disease.
AB - Recent reports have suggested that variability in the α2-macroglobulin gene is a genetic risk factor for Alzheimer's disease. Here we have both tested a common polyrdorphism in the gene (I1000V) for association with the disease in a four-site case control study design, and tested the locus for linkage in a large series of sibpairs afflicted with late onset disease. Our results fail to show an association between this polymorphism and disease.
KW - Alzheimer's disease
KW - Apolipoprotein E
KW - Genetics
KW - α2-macroglobulin
UR - http://www.scopus.com/inward/record.url?scp=0033525766&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(99)00035-X
DO - 10.1016/S0304-3940(99)00035-X
M3 - Article
C2 - 10203250
AN - SCOPUS:0033525766
SN - 0304-3940
VL - 262
SP - 137
EP - 139
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -