No association between polymorphisms in the human dopamine D3 and D4 receptors genes and alcoholism

Abbas Parsian, Sumitra Chakraverty, Lorienne Fisher, C. Robert Cloninger

    Research output: Contribution to journalArticle

    47 Scopus citations

    Abstract

    The human dopamine D2 receptor gene (DRD2) has received considerable attention for the past several years as a potential candidate that may affect susceptibility to alcoholism. The association studies that compared the frequencies of alleles of DRD2 gene between alcoholics and control groups have produced equivocal results. Dopamine D3 and D4 receptor genes (DRD3 and DRD4) are in the same class as DRD9 but with different pharmacological properties. We have used relative risk and haplotype relative risk approaches to test associations between alleles of DRD3 and DRD4 genes and alcoholism. For relative risk studies 162 probands from multiple incidence alcoholic families have been compared to 89 psychiatrically normal controls. Haplotype relative risk approaches have used 29 alcoholic probands in which both parents were available for genotyping. The Bal I restriction enzyme site in DRD3 and tandem repeat (VNTR) in DRD4 genes polymorphisms were used to genotype the above samples. The results of relative risk approaches for both DRD3 and DRD4 genes were negative for comparisons of alcoholics and subtypes of alcoholics with normal controls. Haplotype relative risk approaches also were negative for both genes. These results suggest that any role played by these receptors may account for only part of the variation in susceptibility to alcoholism.

    Original languageEnglish
    Pages (from-to)281-285
    Number of pages5
    JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
    Volume74
    Issue number3
    DOIs
    StatePublished - Jun 26 1997

    Keywords

    • Alcoholism
    • DRD
    • DRD
    • Haplotype relative risk
    • Relative risk

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