TY - JOUR
T1 - NKG2D-independent suppression of T cell proliferation by H60 and MICA
AU - Kriegeskorte, Anja K.
AU - Gebhardt, Friedemann E.
AU - Porcellini, Simona
AU - Schiemann, Matthias
AU - Stemberger, Christian
AU - Franz, Tobias J.
AU - Huster, Katharina M.
AU - Carayannopoulos, Leon N.
AU - Yokoyama, Wayne M.
AU - Colonna, Marco
AU - Siccardi, Antonio G.
AU - Bauer, Stefan
AU - Busch, Dirk H.
PY - 2005/8/16
Y1 - 2005/8/16
N2 - The activating receptor NKG2D recognizes a wide range of different ligands, some of which are primarily expressed in "stressed" tissues or on tumor cells. Until now, similar stimulatory effects on natural killer and CD8+ T cells have been described for all NKG2D ligands, and the NKG2D receptor/ligand system has therefore been interpreted as a sensor system involved in tumor immune surveillance and activation of immune responses. We show here that the NKG2D ligands H60 and MIC class 1 chain-related protein A (MICA) can also mediate strong suppressive effects on T cell proliferation. Responsiveness to H60- and MICA-mediated suppression requires IL-10 and involves a receptor other than NKG2D. These findings might provide explanations for the observation that strong in vivo NKG2D ligand expression, such as that on tumor cells, sometimes fails to support effective immune responses and links this observation to a distinct subgroup of NKG2D ligands.
AB - The activating receptor NKG2D recognizes a wide range of different ligands, some of which are primarily expressed in "stressed" tissues or on tumor cells. Until now, similar stimulatory effects on natural killer and CD8+ T cells have been described for all NKG2D ligands, and the NKG2D receptor/ligand system has therefore been interpreted as a sensor system involved in tumor immune surveillance and activation of immune responses. We show here that the NKG2D ligands H60 and MIC class 1 chain-related protein A (MICA) can also mediate strong suppressive effects on T cell proliferation. Responsiveness to H60- and MICA-mediated suppression requires IL-10 and involves a receptor other than NKG2D. These findings might provide explanations for the observation that strong in vivo NKG2D ligand expression, such as that on tumor cells, sometimes fails to support effective immune responses and links this observation to a distinct subgroup of NKG2D ligands.
KW - Immunology
KW - NKG2D ligands
UR - http://www.scopus.com/inward/record.url?scp=23844495171&partnerID=8YFLogxK
U2 - 10.1073/pnas.0502026102
DO - 10.1073/pnas.0502026102
M3 - Article
C2 - 16091471
AN - SCOPUS:23844495171
SN - 0027-8424
VL - 102
SP - 11805
EP - 11810
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 33
ER -