NK3-specific natural killer cells are selectively inhibited by Bw4-positive HLA alleles with isoleucine 80

Marina Cella, Anna Longo, Giovan Battista Ferrara, Jack L. Strominger, Marco Colonna

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303 Scopus citations

Abstract

Natural kiUer (NK) cell dones have been previously described which are inhibited by HLA-C aUdes with Asn77-LysS0 (NK1-specific cdls) or by HLA-C alldes with Ser77-Asn80 (NK2- specific ceils). In the present work, the generation of NK cells with HLA-B-rdated spedficities was attempted by stimulation of a Bw4 homozygous responder by a Bw6 homozygous donor. Two NK clones were found, which were inhibited by HLA-Bw4 (but not by HLA-Bw6) allotypes and by some HLA-A allotypes that share the Bw4 public epitope. Inhibition of NK cell-mediated lysis strongly correlated with the presence of an Ile residue at position 80 of the protective allele. These NK cell clones define a new specificity termed NK3.

Original languageEnglish
Pages (from-to)1235-1242
Number of pages8
JournalJournal of Experimental Medicine
Volume180
Issue number4
DOIs
StatePublished - Oct 1 1994

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