Abstract

Natural killer (NK) cells demonstrate potent activity against a variety of viruses. The most important features of the antiviral response include NK cell activation, cytotoxic and cytokine-mediated effector functions, and interaction with other immune cells. The mechanisms utilized by NK cells to sense and respond to infection have been characterized in both humans and mice. In this article, we review our current understanding of how NK cells contribute to antiviral defenses.

Original languageEnglish
Title of host publicationImmunity to Pathogens and Tumors
PublisherElsevier Inc.
Pages243-252
Number of pages10
Volume4
ISBN (Print)9780080921525
DOIs
StatePublished - Apr 27 2016

Keywords

  • Antiviral
  • Cytotoxicity
  • Granzymes
  • HCMV
  • HIV
  • HLA
  • Immunoevasion
  • Interferon-γ
  • KIR
  • Ly49
  • M157
  • MCMV
  • MHC
  • Missing-self
  • Murine cytomegalovirus
  • NK cells
  • NKG2C
  • Perforin

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  • Cite this

    Parikh, B. A., Piersma, S. J., & Yokoyama, W. M. (2016). NK Cells in Antiviral Defense. In Immunity to Pathogens and Tumors (Vol. 4, pp. 243-252). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374279-7.14006-8