NK Cells in Antiviral Defense

Bijal A. Parikh; Sytse J. Piersma; Wayne M. Yokoyama

doi:10.1016/B978-0-12-374279-7.14006-8

NK Cells in Antiviral Defense

Bijal A. Parikh, Sytse J. Piersma, Wayne M. Yokoyama

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

Natural killer (NK) cells demonstrate potent activity against a variety of viruses. The most important features of the antiviral response include NK cell activation, cytotoxic and cytokine-mediated effector functions, and interaction with other immune cells. The mechanisms utilized by NK cells to sense and respond to infection have been characterized in both humans and mice. In this article, we review our current understanding of how NK cells contribute to antiviral defenses.

Original language	English
Title of host publication	Immunity to Pathogens and Tumors
Publisher	Elsevier Inc.
Pages	243-252
Number of pages	10
Volume	4
ISBN (Print)	9780080921525
DOIs	https://doi.org/10.1016/B978-0-12-374279-7.14006-8
State	Published - Apr 27 2016

Keywords

Antiviral
Cytotoxicity
Granzymes
HCMV
HIV
HLA
Immunoevasion
Interferon-γ
KIR
Ly49
M157
MCMV
MHC
Missing-self
Murine cytomegalovirus
NK cells
NKG2C
Perforin

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10.1016/B978-0-12-374279-7.14006-8

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title = "NK Cells in Antiviral Defense",

abstract = "Natural killer (NK) cells demonstrate potent activity against a variety of viruses. The most important features of the antiviral response include NK cell activation, cytotoxic and cytokine-mediated effector functions, and interaction with other immune cells. The mechanisms utilized by NK cells to sense and respond to infection have been characterized in both humans and mice. In this article, we review our current understanding of how NK cells contribute to antiviral defenses.",

keywords = "Antiviral, Cytotoxicity, Granzymes, HCMV, HIV, HLA, Immunoevasion, Interferon-γ, KIR, Ly49, M157, MCMV, MHC, Missing-self, Murine cytomegalovirus, NK cells, NKG2C, Perforin",

author = "Parikh, {Bijal A.} and Piersma, {Sytse J.} and Yokoyama, {Wayne M.}",

year = "2016",

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T1 - NK Cells in Antiviral Defense

AU - Parikh, Bijal A.

AU - Piersma, Sytse J.

AU - Yokoyama, Wayne M.

PY - 2016/4/27

Y1 - 2016/4/27

N2 - Natural killer (NK) cells demonstrate potent activity against a variety of viruses. The most important features of the antiviral response include NK cell activation, cytotoxic and cytokine-mediated effector functions, and interaction with other immune cells. The mechanisms utilized by NK cells to sense and respond to infection have been characterized in both humans and mice. In this article, we review our current understanding of how NK cells contribute to antiviral defenses.

AB - Natural killer (NK) cells demonstrate potent activity against a variety of viruses. The most important features of the antiviral response include NK cell activation, cytotoxic and cytokine-mediated effector functions, and interaction with other immune cells. The mechanisms utilized by NK cells to sense and respond to infection have been characterized in both humans and mice. In this article, we review our current understanding of how NK cells contribute to antiviral defenses.

KW - Antiviral

KW - Cytotoxicity

KW - Granzymes

KW - HCMV

KW - HIV

KW - HLA

KW - Immunoevasion

KW - Interferon-γ

KW - KIR

KW - Ly49

KW - M157

KW - MCMV

KW - MHC

KW - Missing-self

KW - Murine cytomegalovirus

KW - NK cells

KW - NKG2C

KW - Perforin

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U2 - 10.1016/B978-0-12-374279-7.14006-8

DO - 10.1016/B978-0-12-374279-7.14006-8

M3 - Chapter

AN - SCOPUS:85042926577

SN - 9780080921525

VL - 4

SP - 243

EP - 252

BT - Immunity to Pathogens and Tumors

PB - Elsevier Inc.

ER -

NK Cells in Antiviral Defense

Abstract

Keywords

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