TY - JOUR
T1 - Nitric oxide synthase inhibitor, aminoguanidine, reduces inflammation and demyelination produced by Theiler's virus infection
AU - Rose, John W.
AU - Hill, Kenneth E.
AU - Wada, Yoshiaki
AU - Kurtz, Caroline I.B.
AU - Tsunoda, Ikuo
AU - S. Fujinami, Robert
AU - Cross, Anne H.
N1 - Funding Information:
The authors wish to thank Manuel San for technical assistance as well as Syd Crandall and Todd Peterson for assistance with photography and computer imaging. These studies were supported by VA Merit Review funding (J.W.R.) and National Multiple Sclerosis Society Grant RG-2671 (A.H.C.).
PY - 1998/1
Y1 - 1998/1
N2 - This study evaluated effects of the inducible nitric oxide synthase (iNOS) inhibitor, aminoguanidine (AG), on the neuropathology and clinical disease produced by Theiler's murine encephalomyelitis virus (TMEV) DA strain infection. Treatment with AG was started on day 7, 14, 28 or 66 post- inoculation and continued for a minimum of 21 days. Inflammation, demyelination and axonal necrosis were scored in a blinded fashion spinal cord sections from each mouse. Reduction in inflammation, demyelination and axonal necrosis was observed in mice treated with AG. Apoptosis within the spinal cord parenchyma and perivascular cuffs was significantly decreased. AG treatment resulted in delayed onset of clinical disease.
AB - This study evaluated effects of the inducible nitric oxide synthase (iNOS) inhibitor, aminoguanidine (AG), on the neuropathology and clinical disease produced by Theiler's murine encephalomyelitis virus (TMEV) DA strain infection. Treatment with AG was started on day 7, 14, 28 or 66 post- inoculation and continued for a minimum of 21 days. Inflammation, demyelination and axonal necrosis were scored in a blinded fashion spinal cord sections from each mouse. Reduction in inflammation, demyelination and axonal necrosis was observed in mice treated with AG. Apoptosis within the spinal cord parenchyma and perivascular cuffs was significantly decreased. AG treatment resulted in delayed onset of clinical disease.
KW - Aminoguanidine
KW - Apoptosis
KW - Nitric oxide synthase
KW - Theiler's murine encephalomyelitis virus
UR - http://www.scopus.com/inward/record.url?scp=0031809195&partnerID=8YFLogxK
U2 - 10.1016/S0165-5728(97)00162-8
DO - 10.1016/S0165-5728(97)00162-8
M3 - Article
C2 - 9521609
AN - SCOPUS:0031809195
SN - 0165-5728
VL - 81
SP - 82
EP - 89
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -