Nitric oxide mediates mecamylamine- and naloxone-precipitated nicotine withdrawal

Michael L. Adams, Theodore J. Cicero

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

A nitric oxide synthase inhibitor blocked nicotine abstinence signs and increased weight loss in male, nicotine-dependent rats during withdrawal precipitated by the nicotinic receptor antagonist mecamylamine or the opioid receptor antagonist naloxone. These results indicate that nitric oxide systems mediate important aspects of the expression of nicotine physical dependence and suggest the potential use of nitric oxide synthase inhibitors as aids in tobacco smoking cessation.

Original languageEnglish
Pages (from-to)R1-R2
JournalEuropean Journal of Pharmacology
Volume345
Issue number2
DOIs
StatePublished - Mar 19 1998

Keywords

  • Nicotine dependence
  • Nitric oxide (NO)

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