Nitric oxide mediates mecamylamine- and naloxone-precipitated nicotine withdrawal

Michael L. Adams; Theodore J. Cicero

doi:10.1016/S0014-2999(98)00089-2

Nitric oxide mediates mecamylamine- and naloxone-precipitated nicotine withdrawal

Michael L. Adams, Theodore J. Cicero

Department of Psychiatry

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

A nitric oxide synthase inhibitor blocked nicotine abstinence signs and increased weight loss in male, nicotine-dependent rats during withdrawal precipitated by the nicotinic receptor antagonist mecamylamine or the opioid receptor antagonist naloxone. These results indicate that nitric oxide systems mediate important aspects of the expression of nicotine physical dependence and suggest the potential use of nitric oxide synthase inhibitors as aids in tobacco smoking cessation.

Original language	English
Pages (from-to)	R1-R2
Journal	European Journal of Pharmacology
Volume	345
Issue number	2
DOIs	https://doi.org/10.1016/S0014-2999(98)00089-2
State	Published - Mar 19 1998

Keywords

Nicotine dependence
Nitric oxide (NO)

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10.1016/S0014-2999(98)00089-2

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title = "Nitric oxide mediates mecamylamine- and naloxone-precipitated nicotine withdrawal",

abstract = "A nitric oxide synthase inhibitor blocked nicotine abstinence signs and increased weight loss in male, nicotine-dependent rats during withdrawal precipitated by the nicotinic receptor antagonist mecamylamine or the opioid receptor antagonist naloxone. These results indicate that nitric oxide systems mediate important aspects of the expression of nicotine physical dependence and suggest the potential use of nitric oxide synthase inhibitors as aids in tobacco smoking cessation.",

keywords = "Nicotine dependence, Nitric oxide (NO)",

author = "Adams, {Michael L.} and Cicero, {Theodore J.}",

note = "Funding Information: We thank Jingling Chen and William D. Johnson for technical help. This work was supported by NIH grant DA08366 of the National Institute on Drug Abuse.",

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AU - Adams, Michael L.

AU - Cicero, Theodore J.

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PY - 1998/3/19

Y1 - 1998/3/19

N2 - A nitric oxide synthase inhibitor blocked nicotine abstinence signs and increased weight loss in male, nicotine-dependent rats during withdrawal precipitated by the nicotinic receptor antagonist mecamylamine or the opioid receptor antagonist naloxone. These results indicate that nitric oxide systems mediate important aspects of the expression of nicotine physical dependence and suggest the potential use of nitric oxide synthase inhibitors as aids in tobacco smoking cessation.

AB - A nitric oxide synthase inhibitor blocked nicotine abstinence signs and increased weight loss in male, nicotine-dependent rats during withdrawal precipitated by the nicotinic receptor antagonist mecamylamine or the opioid receptor antagonist naloxone. These results indicate that nitric oxide systems mediate important aspects of the expression of nicotine physical dependence and suggest the potential use of nitric oxide synthase inhibitors as aids in tobacco smoking cessation.

KW - Nicotine dependence

KW - Nitric oxide (NO)

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U2 - 10.1016/S0014-2999(98)00089-2

DO - 10.1016/S0014-2999(98)00089-2

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AN - SCOPUS:0032546327

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JF - European Journal of Pharmacology

IS - 2

ER -

Nitric oxide mediates mecamylamine- and naloxone-precipitated nicotine withdrawal

Abstract

Keywords

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