TY - JOUR
T1 - Nitric oxide control of steroidogenesis
T2 - Endocrine effects of NG-nitro-L-arginine and comparisons to alcohol
AU - Adams, Michael L.
AU - Nock, Bruce
AU - Truong, Rosalie
AU - Cicero, Theodore J.
N1 - Funding Information:
Supported in part by AA-03539a nd AA-07144 from the National Instituteo n Alcohol Abuse and Alcoholism,D A-03833a nd DA-05816f rom the NationalI nstituteo n Drug Abuse, and GM-24483f rom the NationalI nstituteso f Health. TheodoreJ . Cicero is a recipiento f ResearchS cientistA ward DA-00095a nd Bruce Nock is a recipiento f ResearchS cientistD evelopmenAt ward DA-00157f romt he NationalI nstituteo n Drug Abuse. We thank Myrtle Barrett, Edward R. Meyer, and Michele Wick for their expert technical assistance.
PY - 1992
Y1 - 1992
N2 - Recent studies suggest that nitric oxide (NO) may regulate hormone biosynthesis and secretion. This was tested by treating male rats with NG-nitro-L-arginine methyl ester (NAME), a NO synthase inhibitor, and measuring serum and testicular interstitial fluid testosterone and serum corticosterone, luteinizing hormone (LH), and prolactin (PRL). The effect of NG-nitro-L-arginine (NA), a less-soluble form of the same NO synthase inhibitor, on the reproductive suppressant actions of alcohol was also examined. NAME increased testosterone and corticosterone secretion dose-dependently without affecting LH and PRL secretion. The alcohol-induced suppression of testosterone or LH secretion was not altered by treatment with NA. Although effects of NAME and NA on other systems may be involved, these results indicate that testicular and adrenal steroidogenesis are negatively regulated by endogenos NO and that NO does not regulate LH and PRL secretion or inhibit the testicular steroidogenic pathway in the same way as alcohol.
AB - Recent studies suggest that nitric oxide (NO) may regulate hormone biosynthesis and secretion. This was tested by treating male rats with NG-nitro-L-arginine methyl ester (NAME), a NO synthase inhibitor, and measuring serum and testicular interstitial fluid testosterone and serum corticosterone, luteinizing hormone (LH), and prolactin (PRL). The effect of NG-nitro-L-arginine (NA), a less-soluble form of the same NO synthase inhibitor, on the reproductive suppressant actions of alcohol was also examined. NAME increased testosterone and corticosterone secretion dose-dependently without affecting LH and PRL secretion. The alcohol-induced suppression of testosterone or LH secretion was not altered by treatment with NA. Although effects of NAME and NA on other systems may be involved, these results indicate that testicular and adrenal steroidogenesis are negatively regulated by endogenos NO and that NO does not regulate LH and PRL secretion or inhibit the testicular steroidogenic pathway in the same way as alcohol.
UR - http://www.scopus.com/inward/record.url?scp=0026601933&partnerID=8YFLogxK
U2 - 10.1016/0024-3205(92)90384-2
DO - 10.1016/0024-3205(92)90384-2
M3 - Article
C2 - 1734158
AN - SCOPUS:0026601933
VL - 50
SP - PL35-PL40
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 6
ER -