Nipping at cardiac remodeling

Russell S. Whelan; Kartik Mani; Richard N. Kitsis

doi:10.1172/JCI33706

Nipping at cardiac remodeling

Russell S. Whelan
, Kartik Mani
, Richard N. Kitsis

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

Much of the mortality following myocardial infarction results from remodeling of the heart after the acute ischemic event. Cardiomyocyte apoptosis has been thought to play a key role in this remodeling process. In this issue of the JCI, Diwan and colleagues present evidence that Bnip3, a proapoptotic Bcl2 family protein, mediates cardiac enlargement, reshaping, and dysfunction in mice without influencing infarct size (see the related article beginning on page 2825).

Original language	English
Pages (from-to)	2751-2753
Number of pages	3
Journal	Journal of Clinical Investigation
Volume	117
Issue number	10
DOIs	https://doi.org/10.1172/JCI33706
State	Published - Oct 1 2007

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10.1172/JCI33706

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title = "Nipping at cardiac remodeling",

abstract = "Much of the mortality following myocardial infarction results from remodeling of the heart after the acute ischemic event. Cardiomyocyte apoptosis has been thought to play a key role in this remodeling process. In this issue of the JCI, Diwan and colleagues present evidence that Bnip3, a proapoptotic Bcl2 family protein, mediates cardiac enlargement, reshaping, and dysfunction in mice without influencing infarct size (see the related article beginning on page 2825).",

author = "Whelan, \{Russell S.\} and Kartik Mani and Kitsis, \{Richard N.\}",

year = "2007",

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T1 - Nipping at cardiac remodeling

AU - Whelan, Russell S.

AU - Mani, Kartik

AU - Kitsis, Richard N.

PY - 2007/10/1

Y1 - 2007/10/1

N2 - Much of the mortality following myocardial infarction results from remodeling of the heart after the acute ischemic event. Cardiomyocyte apoptosis has been thought to play a key role in this remodeling process. In this issue of the JCI, Diwan and colleagues present evidence that Bnip3, a proapoptotic Bcl2 family protein, mediates cardiac enlargement, reshaping, and dysfunction in mice without influencing infarct size (see the related article beginning on page 2825).

AB - Much of the mortality following myocardial infarction results from remodeling of the heart after the acute ischemic event. Cardiomyocyte apoptosis has been thought to play a key role in this remodeling process. In this issue of the JCI, Diwan and colleagues present evidence that Bnip3, a proapoptotic Bcl2 family protein, mediates cardiac enlargement, reshaping, and dysfunction in mice without influencing infarct size (see the related article beginning on page 2825).

UR - https://www.scopus.com/pages/publications/34948820283

U2 - 10.1172/JCI33706

DO - 10.1172/JCI33706

M3 - Review article

C2 - 17909620

AN - SCOPUS:34948820283

SN - 0021-9738

VL - 117

SP - 2751

EP - 2753

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

IS - 10

ER -

Nipping at cardiac remodeling

Abstract

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