Nifedipine blockade of ergonovine-lnduced coronary arterial spasm: Angiographic documentations

Alan J. Tiefenbrunn, Burton E. Sobel, Siddhesh Gowda, Obert C. Mcknight, Philip A. Ludbrook

Research output: Contribution to journalArticlepeer-review


To determine whether calcium-flux blockade with nifedipine blunts coronary vasospasm, four patients with angiographically demonstrable coronary arterial spasm in the absence of Significant fixed coronary arterial stenosis were evaluated with coronary arteriography before and after treatment with nifedipine. After initial coronary arteriography, ergonovine was administered in successive doses of 0.05, 0.1 and (when necessary) 0.2 mg intravenously at 3 minute intervals. Three patients had symptomatic high grade focal coronary arterial spasm with electrocardiographic changes, and the fourth exhibited asymptomatic 60 percent constriction of the left anterior descending coronary artery. A maximal ergonovine challenge was repeated 30 minutes later after each patient had been pretreated with a 20 mg sublingual dose of nifedipine. Under these conditions, no patient had chest pain or electrocardiographic changes. Furthermore, neither focal nor diffuse coronary arterial spasm was demonstrable angiographically after the second challenge. Thus, in each case, a single dose of nifedipine precluded the angiographie expression of ergonovine-provoked coronary arterial spasm.

Original languageEnglish
Pages (from-to)184-187
Number of pages4
JournalThe American journal of cardiology
Issue number1
StatePublished - Jul 1981


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