TY - JOUR
T1 - NFAT gene family in inflammation and cancer
AU - Pan, M. G.
AU - Xiong, Y.
AU - Chen, F.
PY - 2013
Y1 - 2013
N2 - Calcineurin-NFAT signaling is critical for numerous aspects of vertebrate function during and after embryonic development. Initially discovered in T cells, the NFAT gene family, consisting of five members, regulates immune system, inflammatory response, angiogenesis, cardiac valve formation, myocardial development, axonal guidance, skeletal muscle development, bone homeostasis, development and metastasis of cancer, and many other biological processes. In this review we will focus on the NFAT literature relevant to the two closely related pathological systems: inflammation and cancer.
AB - Calcineurin-NFAT signaling is critical for numerous aspects of vertebrate function during and after embryonic development. Initially discovered in T cells, the NFAT gene family, consisting of five members, regulates immune system, inflammatory response, angiogenesis, cardiac valve formation, myocardial development, axonal guidance, skeletal muscle development, bone homeostasis, development and metastasis of cancer, and many other biological processes. In this review we will focus on the NFAT literature relevant to the two closely related pathological systems: inflammation and cancer.
KW - Calcineurin
KW - Cancer
KW - Inflammation
KW - NFAT
KW - Nuclear export
KW - Nuclear import
UR - http://www.scopus.com/inward/record.url?scp=84876737068&partnerID=8YFLogxK
U2 - 10.2174/1566524011313040007
DO - 10.2174/1566524011313040007
M3 - Review article
C2 - 22950383
AN - SCOPUS:84876737068
SN - 1566-5240
VL - 13
SP - 543
EP - 554
JO - Current Molecular Medicine
JF - Current Molecular Medicine
IS - 4
ER -