NFAT gene family in inflammation and cancer

M. G. Pan, Y. Xiong, F. Chen

Research output: Contribution to journalReview articlepeer-review

117 Scopus citations

Abstract

Calcineurin-NFAT signaling is critical for numerous aspects of vertebrate function during and after embryonic development. Initially discovered in T cells, the NFAT gene family, consisting of five members, regulates immune system, inflammatory response, angiogenesis, cardiac valve formation, myocardial development, axonal guidance, skeletal muscle development, bone homeostasis, development and metastasis of cancer, and many other biological processes. In this review we will focus on the NFAT literature relevant to the two closely related pathological systems: inflammation and cancer.

Original languageEnglish
Pages (from-to)543-554
Number of pages12
JournalCurrent Molecular Medicine
Volume13
Issue number4
DOIs
StatePublished - 2013

Keywords

  • Calcineurin
  • Cancer
  • Inflammation
  • NFAT
  • Nuclear export
  • Nuclear import

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